The vicious cycle towards violence: focus on the negative feedback mechanisms of brain serotonin neurotransmission.

Frontiers in Behavioral Neuroscience
Sietse F De BoerJaap M Koolhaas

Abstract

Violence can be defined as a form of escalated aggressive behavior that is expressed out of context and out of inhibitory control, and apparently has lost its adaptive function in social communication. Little is known about the social and environmental factors as well as the underlying neurobiological mechanisms involved in the shift of normal adaptive aggression into violence. In an effort to model the harmful acts of aggression and violence in humans, we recently (re)developed an animal model that is focused on engendering uncontrolled forms of maladaptive aggressive behavior in laboratory-bred feral rats and mice. We show that certain (8-12%) constitutionally aggressive individuals gradually develop, over the course of repetitive exposures to victorious social conflicts, escalated (short-latency, high-frequency and ferocious attacks), persistent (lack of attack inhibition by defeat/submission signals and perseverance of the aggressive attack-biting bout), indiscriminating (attacking female and anesthetized male intruders) and injurious (enhanced vulnerable-body region attacks and inflicted wounding) forms of offensive aggression. Based on the neurobiological results obtained using this model, a revised view is presented on t...Continue Reading

Citations

Nov 17, 2012·PloS One·Madelene Åberg Andersson, Erik Höglund
Apr 30, 2013·Psychopharmacology·Federica CalcagnoliJaap M Koolhaas
Jan 8, 2013·Behavioural Brain Research·Rebecca S HeimingNorbert Sachser
Feb 7, 2012·Sleep Medicine·Jeanine KamphuisMarike Lancel
Jun 28, 2011·Research in Developmental Disabilities·Michael E May
Apr 13, 2010·Frontiers in Neuroendocrinology·J M KoolhaasB Buwalda
Mar 19, 2016·Neuroscience and Biobehavioral Reviews·Laura SteenbergenLorenza S Colzato
Jan 28, 2014·Aggressive Behavior·Caroline M CoppensJaap M Koolhaas
Aug 19, 2015·Annals of the New York Academy of Sciences·Klaus A MiczekRosa M M de Almeida
Jun 13, 2015·Physiology & Behavior·S F de BoerJ M Koolhaas
May 6, 2015·Current Opinion in Behavioral Sciences·Klaus A MiczekRosa M M de Almeida
Dec 31, 2011·Neuroscience and Biobehavioral Reviews·Dominik KiserJudith R Homberg
Jan 11, 2014·Behavioural Brain Research·Federica CalcagnoliInga D Neumann
Mar 4, 2015·The International Journal of Neuropsychopharmacology·Koen HogenelstMarije Aan Het Rot
Dec 19, 2014·Proceedings. Biological Sciences·Stephen M Rogers, Swidbert R Ott
Jul 25, 2012·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Klaus-Peter LeschLise Gutknecht

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