The Viscum album preparation Isorel inhibits the growth of melanoma B16F10 by influencing the tumour-host relationship

Anti-cancer Drugs
N ZarkovicM Jurin

Abstract

The aim of this study was to analyse whether Viscum album (mistletoe; Isorel) modulates the tumour-host relationship and whether this might be a basic mechanism of the antitumorous activity of the drug. The effects of a single intraperitoneal injection of the drug (100 mg/kg single 'planta tota' dose) were analysed for mice-bearing melanoma B16F10 growing in the hind limb. Injection of Isorel reduced the size of the tumour and caused abundant tumour necrosis with inflammatory response, oedema and destruction of the malignant tissue. Furthermore, the lymphocytes of saline-treated tumorous mice were not able to respond to the mitogenic lectin concanavalin A in vitro, while those of mistletoe extract-treated mice showed high reactivity too the mitogen, but only if cultured in the medium supplemented with the plasma of the mistletoe extract-treated mice. Moreover, melanoma cells exposed to the mistletoe extract were more sensitive to the cytotoxic activity of the lymphocytes than the control tumour cells, particularly in the presence of the plasma of mistletoe extract-treated mice. The plasma itself, however, did not show any cytotoxic activity. These results indicate that the antitumour activity of the mistletoe drug is due to a m...Continue Reading

Citations

Jan 13, 2006·BioFactors·Morana ZivkovicNeven Zarkovic
Jan 8, 1999·Biochimica Et Biophysica Acta·G M SteinA Büssing
Mar 31, 2001·Cancer Biotherapy & Radiopharmaceuticals·N ZarkovicS Mang
Apr 2, 2003·Cancer Biotherapy & Radiopharmaceuticals·Mircea CazacuNeven Zarkovic
Dec 5, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D RansomT J Price
Jun 10, 2017·Experimental and Therapeutic Medicine·Leoni Villano BonaminSilvia Waisse
Mar 28, 2006·Cancer Letters·Morana ZivkovicNeven Zarkovic
Dec 18, 2007·Cancer Letters·Morana JaganjacNeven Zarkovic
Feb 4, 2010·Immunobiology·Morana JaganjacNeven Zarkovic

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