PMID: 8962163Dec 10, 1996Paper

The visual response of retinal ganglion cells is not altered by optic nerve transection in transgenic mice overexpressing Bcl-2

Proceedings of the National Academy of Sciences of the United States of America
V PorciattiL Maffei

Abstract

Attempts to rescue retinal ganglion cells from retrograde degeneration have had limited success, and the residual function of surviving neurons is not known. Recently, it has been found that axotomized retinal ganglion cells die by apoptotic mechanisms. We have used adult transgenic mice overexpressing the Bcl-2 protein, a powerful inhibitor of apoptosis, as a model for preventing injury-induced cell death in vivo. Several months after axotomy, the majority of retinal ganglion cells survived and exhibited normal visual responses. In control wild-type mice, the vast majority of axotomized retinal ganglion cells degenerated, and the physiological responses were abolished. These results suggest that strategies aimed at increasing Bcl-2 expression, or mimicking its function, might effectively counteract trauma-induced cell death in the central nervous system. Neuronal survival is a necessary condition in the challenge for promoting regeneration and eventually restoring neuronal function.

References

Mar 1, 1990·Electroencephalography and Clinical Neurophysiology·A C Kothe, J V Lovasik
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L MaffeiG Ferrari
Jan 1, 1990·Experimental Brain Research·N BerardiL Maffei
Jan 1, 1987·Journal of Neurophysiology·P A Sieving, R H Steinberg
Jan 1, 1985·Vision Research·S Remtulla, P E Hallett
Jan 1, 1985·Experimental Brain Research·L MaffeiH Holländer
Jan 1, 1982·Experimental Brain Research·L Maffei, A Fiorentini
Aug 1, 1995·Trends in Neurosciences·A M Davies
Jan 1, 1995·The European Journal of Neuroscience·K R HuxlinM R Bennett
Mar 1, 1995·Trends in Genetics : TIG·S J Korsmeyer
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S Mansour-RobaeyA J Aguayo
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·M Dubois-DauphinJ C Martinou
Nov 1, 1994·Trends in Cell Biology·B A Osborne, L M Schwartz

❮ Previous
Next ❯

Citations

Mar 4, 2000·The Journal of Comparative Neurology·M Salvador-SilvaM P Villegas-Pérez
Mar 29, 2002·The Journal of Comparative Neurology·Enrica Strettoi, Maila Volpini
Dec 4, 2002·Journal of Cellular Biochemistry·Edward Chaum
May 25, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Vittorio Porciatti
Aug 8, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Cécile PéantFlorence Chiodini
Jul 23, 1999·Survey of Ophthalmology·N N OsborneM S Nash
Jun 15, 1999·Brain Research. Developmental Brain Research·D W RickmanC Bowes Rickman
Nov 16, 2002·Progress in Retinal and Eye Research·Masami Watanabe, Yutaka Fukuda
May 14, 2003·Progress in Retinal and Eye Research·Stefan IsenmannAlessandro Cellerino
Oct 20, 1998·Progress in Retinal and Eye Research·C E ReméA Wenzel
Jun 26, 1999·The European Journal of Neuroscience·L Rondi-ReigJ Mariani
Dec 1, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Vittorio Porciatti, Lori M Ventura
Jun 19, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·V ParisiG Coppola
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Vittorio PorciattiWilliam Buchser
Nov 15, 2012·Investigative Ophthalmology & Visual Science·Tsung-Han Chou, Vittorio Porciatti
Jan 12, 2013·Investigative Ophthalmology & Visual Science·Tsung-Han ChouVittorio Porciatti
Feb 21, 2013·Investigative Ophthalmology & Visual Science·Xu YangVittorio Porciatti
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·F M RossiJ P Changeux
Oct 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M O PéquignotM Abitbol
Dec 29, 2009·Experimental Eye Research·Vittorio Porciatti, Mahesh Nagaraju
Mar 3, 2009·Experimental Eye Research·Gen MiuraLaura J Frishman
May 24, 2015·Experimental Eye Research·Vittorio Porciatti
Apr 22, 2006·Experimental Eye Research·Gil Ben-Shlomo, Ron Ofri
Mar 5, 2004·Biochimica Et Biophysica Acta·Rizwan S AkhtarKevin A Roth
Oct 26, 2005·Vision Research·W H Ridder, S Nusinowitz
Feb 9, 2000·Vision Research·V PorciattiL Maffei
Jul 17, 1998·Vision Research·K F So, H K Yip
May 26, 1999·Vision Research·L GianfranceschiL Maffei
Dec 27, 2008·Experimental Eye Research·Jang-Hyeon ChoWilliam H Klein
Aug 20, 2010·Cell Transplantation·Camila Zaverucha-do-ValleRosalia Mendez-Otero
Sep 11, 2003·Journal of Neurophysiology·Stephen M CarcieriSheila Nirenberg
Sep 30, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Davide BarloscioNicola Origlia
May 1, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Zheng-Min WangKuan-Yan Li
Dec 24, 2014·PloS One·Luciano DomeniciLuca Giovannini
Nov 1, 2020·Experimental Eye Research·Ashutosh JnawaliLisa A Ostrin

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis