The visualisation and quantification of human gastrointestinal fat distribution with MRI: a randomised study in healthy subjects

The British Journal of Nutrition
Dian LiuA Steingoetter

Abstract

We aimed to study the fate of fat during digestion. For this purpose, we validated and investigated the non-invasive quantification of gastric and duodenal fat emptying and emulsion processing (creaming and phase separation) using the MRI method iterative decomposition with echo asymmetry and least squares estimation (IDEAL). In total, twelve healthy subjects were studied on two separate visits in a single-blind, randomised, cross-over design study. IDEAL was utilised to repeatedly acquire quantitative fat fraction maps of the gastrointestinal tract after infusion of one of two fat emulsions: E1 (acid stable, droplet size 0·33 mm) and E4 (acid unstable, 0·38 mm). In vitro and in vivo validation was carried out using diluted emulsion and gastric content samples, respectively, and resulted in Lin's concordance correlation coefficients of 1·00 (95% CI 0·98, 1·00) and 0·91 (95% CI 0·87, 0·94), respectively. Fat fraction maps and intragastric emulsion profiles enabled the identification of features of intraluminal phase separation and creaming that were not visible in conventional MRI. Gastric fat emptying was faster for E4 compared with E1 with a difference of 2·5 (95% CI 1·9, 3·1) ml/h. Duodenal content volumes were larger for E1 ...Continue Reading

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Citations

Jun 21, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N Caballero, J Serra
Nov 30, 2019·Frontiers in Nutrition·Andreas SteingoetterPeter Fischer
Mar 28, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dian LiuSebastian Kozerke
Sep 29, 2020·The Proceedings of the Nutrition Society·Paul A M SmeetsMorwarid Mayar
Jan 13, 2021·Critical Reviews in Food Science and Nutrition·Nassim RaoufiJianzhong Han
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Qing GuoDérick Rousseau
May 1, 2018·ACS Applied Materials & Interfaces·Nathalie ScheublePeter Fischer

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