PMID: 18406281Apr 15, 2008Paper

The vitamin d receptor gene and calcium metabolism

Trends in Endocrinology and Metabolism : TEM
S FerrariR Rizzoli

Abstract

Dietary Ca(2+) is essential for the development and maintenance of bone mineral mass. The vitamin D endocrine system plays a fundamental role in the regulation of Ca(2+) homeostasis, and mutations affecting genes implicated in vitamin D metabolism or vitamin D receptor (VDR) functions are responsible for severe alterations in skeletal growth. In addition, vitamin D is also implicated in the pathophysiology and treatment of adult bone disorders associated with impaired mineralization of bone matrix. Very recently, common polymorphisms in the 3'- and 5'-end region of the VDR gene have been suggested as possible determinants of bone mineral mass and, hence, of the risk of osteoporosis. None of these polymorphisms appear to be associated unequivocally with bone mineral mass or biochemical variables of Ca(2+) and phosphate metabolism, except perhaps VDR 3'-end polymorphisms before puberty. As these associations are so inconsistent, interactions with environmental factors, particularly dietary intake, and with other polymorphisms have to be considered.

References

Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N A MorrisonJ A Eisman
Jul 19, 1992·The New England Journal of Medicine·C C JohnstonM Peacock
Oct 1, 1990·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P J KellyP N Sambrook
Apr 13, 1989·The New England Journal of Medicine·H ReichelA W Norman
Dec 1, 1995·Nature Medicine·T CarlingH Melhus
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J A Eisman
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M Peacock
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E A KrallB Dawson-Hughes
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C FleetB Dawson-Hughes
Jun 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsJ A Eisman
Sep 1, 1995·European Journal of Endocrinology·P J KellyJ A Eisman
Sep 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T ChevalleyJ P Bonjour
Feb 2, 1995·The New England Journal of Medicine·D Housman
Nov 1, 1994·The Journal of Clinical Investigation·F G HustmyerJ Christian
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Feb 18, 1993·Nature·C CarlbergW Hunziker
Jun 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Jul 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A TokitaJ A Eisman
Sep 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A G UitterlindenJ P Van Leeuwen
Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L M SalamoneJ A Cauley
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G S Cooper, D M Umbach
Dec 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C GrossD Feldman
Sep 4, 1997·The New England Journal of Medicine·B Dawson-HughesG E Dallal

❮ Previous
Next ❯

Citations

Apr 7, 2005·Molecular Aspects of Medicine·Serge L Ferrari, R Rizzoli
Oct 20, 2009·Nutrition Research Reviews·Viviana CentenoNori Tolosa de Talamoni
Jul 20, 1999·Current Opinion in Rheumatology·S FerrariJ P Bonjour
Jun 27, 2007·The Tohoku Journal of Experimental Medicine·Duygu Gezen-AkSelma Yilmazer
Mar 18, 2009·Pharmacogenomics·Luigi GennariRanuccio Nuti
Jun 6, 2015·International Journal of Molecular Sciences·Fernanda CobayashiMarly Augusto Cardoso
Nov 6, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Viviana A CentenoNori G Tolosa de Talamoni
Mar 23, 2007·Expert Opinion on Pharmacotherapy·Luigi GennariRanuccio Nuti
Jun 23, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·F Massart
May 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Jessica PepeSerge Ferrari
May 17, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J MarcA Kocijancic
Jul 14, 2000·Critical Reviews in Clinical Laboratory Sciences·A W Root
Dec 6, 2018·Journal of Molecular Neuroscience : MN·Erdinç DursunDuygu Gezen-Ak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.