The vitamin D3 analog, maxacalcitol, reduces psoriasiform skin inflammation by inducing regulatory T cells and downregulating IL-23 and IL-17 production

Journal of Dermatological Science
Carren Sy HauShinichi Watanabe

Abstract

Psoriasis is a Th1/Th17-mediated inflammatory dermatosis treated with topical corticosteroids and vitamin D3 analogs (VD3 As). To compare the effects of a VD3 A maxacalcitol and betamethasone valerate (BV) steroid lotion on topical imiquimod (IMQ)-induced psoriasiform skin inflammation. Female BALB/c mice were treated with vehicle, maxacalcitol or BV lotion on the skin for 3 days, and IMQ cream for 6 days. q-PCR, H&E, immunohistochemistry and immunofluorescence studies were performed on skin samples. Additionally, mice were treated with vehicle, maxacalcitol or BV lotion for 3 days and CD4+CD25+ regulatory T cells (Tregs) and CD4+CD25- cells from each group were isolated from lymph nodes. Adoptive transfer of the cells was performed on recipient mice which were treated with IMQ cream for 6 days, and skin samples were obtained for q-PCR and H&E staining. Maxacalcitol and BV were comparable in regards clinical improvement, although maxacalcitol reduced the MHC Class II+ inflammatory cell infiltration more than BV in IMQ skin. While both treatments downregulated IL-17 A, IL-17 F, IL-22, IL-12p40, TNF-α and IL-6 mRNA expression levels, only maxacalcitol downregulated IL-23p19 expression. Significantly increased Foxp3+ cell infiltra...Continue Reading

Citations

Mar 14, 2019·International Immunology·Lokesh A Kalekar, Michael D Rosenblum
Jul 7, 2020·The British Journal of Dermatology·L NussbaumG S Ogg
Jun 30, 2019·Nutrients·Rose Marino, Madhusmita Misra
Jan 26, 2021·Frontiers in Immunology·Massimo De MartinisSebastiano Gangemi
Dec 29, 2020·The Journal of Dermatology·Masahiro FukudaAkihiko Asahina
Aug 12, 2019·Life Sciences·Rebeca Illescas-MontesVíctor J Costela-Ruiz

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