The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity.

European Journal of Human Genetics : EJHG
Guang GuoJean C Shih

Abstract

Genetic studies of delinquent and criminal behavior are rare in spite of the wide recognition that individuals may differ in their propensity for delinquency and criminality. Using 2524 participants in Add Health in the United States, the present study demonstrates a link between the rare 2 repeat of the 30-bp VNTR in the MAOA gene and much higher levels of self-reported serious and violent delinquency. The evidence is based on a statistical association analysis and a functional analysis of MAOA promoter activity using two human brain-derived cell lines: neuroblastoma SH-SY5Y and human glioblastoma 1242-MG. The association analysis shows that men with a 2R report a level of serious delinquency and violent delinquency in adolescence and young adulthood that were about twice (CI: (0.21, 3.24), P=0.025; and CI: (0.37, 2.5), P=0.008 for serious and violent delinquency, respectively) as high as those for participants with the other variants. The results for women are similar, but weaker. In the functional analysis, the 2 repeat exhibits much lower levels of promoter activity than the 3 or 4 repeat.

References

Jun 18, 1988·Lancet·N LenchR Williamson
Jul 1, 1997·Annals of Human Genetics·D Curtis
Apr 16, 1998·American Journal of Human Genetics·R S Spielman, W J Ewens
Jun 13, 1998·American Journal of Human Genetics·M Boehnke, C D Langefeld
Nov 3, 1998·Human Genetics·S Z SabolD Hamer
May 20, 1999·American Journal of Human Genetics·D B AllisonE R Martin
Aug 12, 1999·American Journal of Human Genetics·J C Shih, R F Thompson
Aug 6, 2002·Science·Avshalom CaspiRichie Poulton
Dec 31, 2004·American Journal of Human Genetics·Hua TangNeil J Risch
Apr 5, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Brett C HaberstickJohn K Hewitt
Mar 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andreas Meyer-LindenbergDaniel R Weinberger
Oct 1, 1946·The American Journal of Orthopsychiatry·F J MURPHYH L WITMER

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Citations

Mar 9, 2011·Archives of General Psychiatry·Nelly Alia-KleinRita Z Goldstein
Aug 9, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M IshiiY Kiuchi
Feb 1, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·T OnayaY Kiuchi
Dec 12, 2013·The Psychiatric Quarterly·Kevin M BeaverBrian B Boutwell
Oct 14, 2011·Journal of Applied Genetics·Konstantin A PavlovVladimir P Chekhonin
Sep 4, 2012·Journal of Applied Genetics·Dimitry A ChistiakovVladimir P Chekhonin
Feb 2, 2012·Development and Psychopathology·Daniel E AdkinsEdwin J C G van den Oord
Feb 24, 2010·Journal of Family Psychology : JFP : Journal of the Division of Family Psychology of the American Psychological Association (Division 43)·Steven R H BeachRobert A Philibert
Sep 16, 2011·Population Studies·Jonathan Daw, Guang Guo
Oct 17, 2012·Genes, Brain, and Behavior·D Gallardo-PujolA Maydeu-Olivares
Feb 25, 2014·Forensic Science International : Synergy·Roberto TatarelliPaolo Girardi
Jun 28, 2014·BioMed Research International·Hui LeiShuqiao Yao
Aug 2, 2014·Journal of Psychiatric Research·Dean A StetlerMarco Bortolato
Nov 1, 2012·European Archives of Psychiatry and Clinical Neuroscience·Niki AntypaDan Rujescu
Nov 2, 2014·Genome Génome / Conseil National De Recherches Canada·Yuri ChoiHeui-Soo Kim
Jun 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·David M FergussonMartin A Kennedy
Feb 7, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Matea Nikolac PerkovicNela Pivac
Jan 19, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sean C GodarMarco Bortolato
Feb 15, 2014·Journal of Criminal Justice·Catherine Tuvblad, Kevin M Beaver
Jan 17, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Noèlia Fernàndez-Castillo, Bru Cormand
Sep 9, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kim VeroudeStephen V Faraone
Oct 24, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Regina WaltesChristine M Freitag
Dec 14, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yuhui SunQi Xu
Sep 25, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Robert A PhilibertMeg Gerrard
Feb 25, 2015·International Journal of Law and Psychiatry·María Isabel González-Tapia, Ingrid Obsuth
Jun 4, 2013·Biological Psychiatry·Brett C HaberstickKathleen Mullan Harris
Dec 5, 2012·European Journal of Medicinal Chemistry·Aliuska Morales HelgueraFernanda Borges
Dec 10, 2016·Human Brain Mapping·Patrick EisnerKlaus Mathiak
Apr 27, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dimitry A Chistiakov, Vladimir P Chekhonin
Mar 12, 2013·Journal of Health and Social Behavior·Dalton Conley, Emily Rauscher
Mar 2, 2010·Upsala Journal of Medical Sciences·Niklas Nordquist, Lars Oreland
May 3, 2019·Molecular Biology and Evolution·Nicky StaesBrenda J Bradley
Dec 24, 2011·Molecular and Cellular Biochemistry·Masakazu IshiiYuji Kiuchi

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