The voice quality after laser surgery versus radiotherapy of T1a glottic carcinoma: systematic review and meta-analysis

OncoTargets and Therapy
Guanjiang HuangHongbing Liu

Abstract

The voice quality assessment of laser surgery (LS) in comparison with radiotherapy (RT) remains uncertain in T1a glottic carcinoma treatment. This systematic review and meta-analysis were conducted to compare the voice quality of the two treatments. Searches were conducted in PubMed, EMBASE, and Cochrane with the following index words: glotti*, layn*, vocal cord, vocal, surgery, cordectomy, laser, radiation, irradiation, radiotherapy, cancer, and carcinoma for relative studies that compared the voice quality between LS and RT. Random-effect models were used, and heterogeneity was assessed. A total of 14 studies were included in the analysis, consisting of 1 randomized controlled trial, 1 prospective study, and 12 retrospective studies. RT has increased the maximum phonation time (MPT; mean difference [MD] =-1.89, 95% confidence interval [CI] =-3.66 to -0.11, P=0.04) and decreased the fundamental frequency (MD =14.06, 95% CI =10.30-17.83, P<0.00001) in comparison with LS. No statistical difference was observed between the two groups in terms of Voice Handicap Index, Jitter, Shimmer, and airflow rate. RT may be a better choice for T1a glottic carcinoma treatment compared with LS because patients undergoing RT may have the advanta...Continue Reading

Citations

Apr 9, 2019·Clinical and Experimental Otorhinolaryngology·So Hyun LeeYong Tae Hong
Oct 19, 2019·Radiology and Oncology·Jana MekisIrena Hocevar Boltezar
Sep 29, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Nelson FerreiraFilomena Santos
Jul 18, 2021·Hematology/oncology Clinics of North America·Kristen A EchaniqueMaie A St John
Aug 12, 2021·Ear, Nose, & Throat Journal·Zhi-Min ZhangZhu-Xiang Chen

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