The voyage of stem cell toward terminal differentiation: a brief overview

Acta Biochimica Et Biophysica Sinica
Shalmoli BhattacharyyaKishan Lal Khanduja

Abstract

Presently, worldwide attempts are being made to apply stem cells and stem cell-derived products to a wide range of clinical applications and for the development of cell-based therapies. In order to harness stem cells and manipulate them for therapeutic application, it is very important to understand the basic biology of stem cells and identify the factors that govern the dynamics of these cells in the body. Several signaling pathways have emerged as key regulators of stem cells. Some of these signaling pathways regulate the stem cell's proliferative capacity and therefore act as direct regulators of the stem cell, whereas others are involved in shaping and maintaining the stem cell niche and therefore act as indirect regulators of the stem cell. It is difficult to identify which signaling pathways critically affect the stem cell's behavior and which are important for maintaining the quiescent population. A stem cell receives different extrinsic signals compared with the bulk population and responds to them differently. In order to manipulate these adult cells for therapeutic approaches it is crucial to identify how signaling pathways regulate stem cells either directly by regulating proliferative status or indirectly by influen...Continue Reading

References

Jan 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S RubinP W Finch
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·G SauvageauR K Humphries
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·H M HoffmannJ L Stein
Apr 8, 1998·Current Opinion in Genetics & Development·K Willert, R Nusse
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Nov 6, 1998·Science·J A ThomsonJ M Jones
Jan 5, 1999·Science·H QiS Artavanis-Tsakonas
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
Feb 13, 1999·Cell·C Wylie
Feb 27, 1999·Experimental Cell Research·M V Wiles, B M Johansson
Apr 2, 1999·Science·M F PittengerD R Marshak
Apr 21, 1999·Current Opinion in Cell Biology·Q Eastman, R Grosschedl
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
May 15, 1999·Science·B E PetersenJ P Goff
Jul 3, 1999·The Journal of Biological Chemistry·A HollnagelA Nordheim
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·T TsukuiJ C Belmonte
Dec 28, 1999·Annual Review of Cell and Developmental Biology·J M Wells, D A Melton
Sep 12, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·B de CrombruggheW Huang
Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Sep 30, 2000·Experimental Cell Research·T Kadesch
Apr 5, 2001·Nature·D OrlicP Anversa
Oct 19, 2001·Biochemical and Biophysical Research Communications·S TsutsumiY Kato
Dec 4, 2001·Nature Biotechnology·B E ReubinoffT Ben-Hur
Apr 24, 2002·Seminars in Cell & Developmental Biology·Shahin RafiiDavid Lyden

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