Abstract
One of the proteins encoded by the foot-and-mouth disease virus (FMDV), the VP1 protein, a capsid protein, plays an important role in integrin receptor attachment and humoral immunity-mediated host responses. The integrin receptor recognition motif and an important antigenic epitope exist within the G-H loop, which is comprised of amino acids 134-160 of the VP1 protein. FMDV strain, Asia1/HN/CHA/06, isolated from a pig, was passaged four times in suckling mice and sequenced. Sequencing analyses showed that there was a mutation of the integrin receptor recognition motif Arg-Gly-Asp/Arg-Asp-Asp (RGD/RDD, VP1 143-145) and a VP1 154 serine/Asp (VP1 S154D) mutation in the G-H loop of the VP1 protein. The influence of the RGD/RDD mutation on Asia1 FMDV disease phenotype has been previously studied. In this study, to determine the influence of the VP1 S154D mutation on FMDV Asia1 replication and pathogenicity, two recombinant FMDVs with different residues only at the VP1 154 site were rescued by reverse genetics techniques and their infectious potential in host cells and pathogenicity in pigs were compared. Our data indicates that the VP1 S154D mutation increases the replication level of FMDV Asia1/HN/CHA/06 in BHK-21, IB-RS-2, and PK...Continue Reading
References
Jun 1, 1987·The Journal of General Virology·Q C XieK C McCullough
Aug 24, 1984·Nucleic Acids Research·S ForssH Schaller
Mar 26, 1982·Science·J HollandS VandePol
Jul 1, 1982·Nature·J L BittleF Brown
Feb 15, 1994·Structure·S LeaJ Newman
Apr 8, 1993·Nature·D LoganN Parry
Jan 1, 1993·Progress in Biophysics and Molecular Biology·G J Belsham
Sep 1, 1995·Virus Research·M G Mateu
May 31, 1996·The Journal of Biological Chemistry·M G MateuE Domingo
Apr 1, 1997·The EMBO Journal·E A HewatD I Stuart
Jan 1, 1997·Annual Review of Microbiology·E Domingo, J J Holland
Jun 6, 1998·Trends in Microbiology·D J Evans, J W Almond
Jan 16, 2003·Virus Research·Peter W MasonBarry Baxt
Feb 14, 2003·Journal of Virology·Qizu ZhaoPeter W Mason
Apr 29, 2005·Journal of Virology·C CarrilloD L Rock
Jun 16, 2005·Journal of Virology·Vivian O'DonnellBarry Baxt
May 25, 2007·Journal of Virology·José I NúñezFrancisco Sobrino
Sep 18, 2008·The Journal of General Virology·Mónica Gutiérrez-RivasMargarita Sáiz
Jun 23, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J S Malik PeirisYi Guan
Jun 27, 2009·Intervirology·J Ruiz-SáenzA López-Herrera
Jun 30, 2011·BMC Microbiology·Pinghua LiZaixin Liu
Jan 4, 2013·Virology Journal·Paul LawrenceElizabeth Rieder
Feb 2, 2013·PloS One·Haixue ZhengXuepeng Cai
Jan 21, 2014·Veterinary Microbiology·Veronica FowlerPaul Barnett
Jan 24, 2014·Journal of Virology·Jianxiong ZengLi Yu
Jun 21, 2015·Virus Research·Kaiqi LianXiangtao Liu
Citations
Feb 9, 2017·Transboundary and Emerging Diseases·X ZhaoJ Ma
Feb 1, 2019·Journal of Virology·Xing-Wen BaiJian-Xun Luo
Feb 8, 2019·Journal of Virology·Zixiang ZhuHaixue Zheng
Nov 30, 2019·Virus Genes·Veronika Dill, Michael Eschbaumer
Sep 27, 2018·Frontiers in Microbiology·Ruoqing MaoXiangtao Liu
Dec 12, 2017·BioMed Research International·Huisheng LiuHaixue Zheng
Sep 13, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiangle ZhangHaixue Zheng
Nov 25, 2020·PLoS Pathogens·Pathum EkanayakaJong-Soo Lee