PMID: 8972570Jan 1, 1996Paper

The VP3 gene of human group C rotavirus

Virus Genes
A R Samarbaf-ZadehI N Clarke

Abstract

The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence motifs. Human group C rotavirus genome segment 4 is 2,166bp long and encodes a single open reading frame of 2,082 nucleotides (693 amino acids) starting at nucleotide 55 and terminating at nucleotide 2,136 giving a 3' untranslated region of 30 nucleotides. Alignment with the porcine group C VP3 equivalent gene showed the human gene is one amino acid longer, and that the proteins have 84.1% amino acid sequence identity. A conserved potential nucleotide binding motif shared with the porcine VP3 sequence was identified. Analogy with the group A rotaviruses suggested that the genome segment 4 encodes the group C rotavirus guanylyltransferase.

References

Mar 1, 1992·Journal of Virology·P R LambdenI N Clarke
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Mar 1, 1990·Journal of Medical Virology·E O CaulJ C Bridger
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Jan 1, 1994·Current Topics in Microbiology and Immunology·B V Prasad, W Chiu

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Citations

Feb 28, 2002·Biochemical and Biophysical Research Communications·Cindy L Luongo

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