Abstract
Foot-and-mouth disease is a frequently occurring disease of cloven-hoofed animals that is caused by infection with the foot-and-mouth virus (FMDV). FMDV circumvents the type-I IFN response by expressing proteins that antagonize cellular innate immunity, such as leader protease and 3C protease. We identified the FMDV structural protein VP3 as a negative regulator of the virus-triggered IFN-β signaling pathway. Expression of FMDV VP3 inhibited the Sendai virus-triggered activation of IFN regulatory factor-3 and the expression of retinoic acid-inducible gene-I/melanoma differentiation-associated protein-5. Transient transfection and coimmunoprecipitation confirmed that the structural protein VP3 interacts with virus-induced signaling adapter (VISA), which is dependent on the C-terminal aa 111-220 of VP3. In addition, we found that FMDV VP3 inhibits the expression of VISA by disrupting its mRNA. Taken together, our findings reveal a novel strategy used by the structural VP3 protein of FMDV to evade host innate immunity.-Li, D., Yang, W., Yang, F., Liu, H., Zhu, Z., Lian, K., Lei, C., Li, S., Liu, X., Zheng, H., Shu, H. The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-β signaling pathway.
References
Aug 1, 1991·Journal of Virological Methods·O MarquardtO C Straub
Nov 1, 1990·Virology·J D KitsonG J Belsham
Nov 1, 1988·Journal of Virology·M A DevaneyM J Grubman
Jan 1, 1968·Archiv für die gesamte Virusforschung·R F SellersW A Snowdon
Apr 1, 1993·Virology·M J Jensen, D M Moore
Jan 1, 1993·Progress in Biophysics and Molecular Biology·G J Belsham
Mar 28, 1998·The EMBO Journal·M YoneyamaT Fujita
Apr 16, 1998·FEBS Letters·M SatoT Taniguchi
Nov 13, 1999·Journal of Virology·J ChinsangaramM J Grubman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Oct 9, 2002·Comparative Immunology, Microbiology and Infectious Diseases·Esteban DomingoFrancisco Sobrino
Aug 30, 2005·Cell·Rashu B SethZhijian J Chen
Aug 30, 2005·Nature Immunology·Taro KawaiShizuo Akira
Sep 13, 2005·Molecular Cell·Liang-Guo XuHong-Bing Shu
Sep 24, 2005·Nature·Etienne MeylanJürg Tschopp
Nov 11, 2005·The EMBO Journal·Jun HuangHong-Bing Shu
Jan 28, 2006·Journal of Virology·Teresa de Los SantosMarvin J Grubman
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yueh-Ming LooMichael Gale
Apr 21, 2006·Nature·Hiroki KatoShizuo Akira
May 30, 2006·Journal of Virology·Rongtuan LinJohn Hiscott
Sep 19, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Apr 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yan YangStanley M Lemon
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mariko MoniwaPaul R Kitching
Jun 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Feici DiaoHong-Bing Shu
Sep 21, 2007·Journal of Virology·Teresa de Los SantosMarvin J Grubman
Mar 22, 2008·Viral Immunology·Charles K NfonWilliam T Golde
Sep 27, 2008·Immunity·Bo ZhongHong-Bing Shu
Jan 6, 2009·Immunological Reviews·Mitsutoshi Yoneyama, Takashi Fujita
Jun 2, 2009·Nature Immunology·Chen WangXuetao Cao
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Congwen WeiHui Zhong
Jul 20, 2010·Biochemical and Biophysical Research Communications·Dang WangShaobo Xiao
Nov 12, 2010·Journal of Virology·Manish KumarBetty L Slagle
Dec 15, 2010·Immunity·Cao-Qi LeiHong-Bing Shu
Feb 11, 2011·Journal of Virology·Dang WangShaobo Xiao
Mar 26, 2011·PLoS Pathogens·Amitava MukherjeeCarolyn B Coyne
Nov 1, 2011·Virology·Manuel V BorcaMaria E Piccone
Nov 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming-Him James NgDong-Yan Jin
Jun 22, 2012·Journal of Virology·Dang WangShaobo Xiao
Apr 5, 2013·PLoS Pathogens·Bei WangZhendong Zhao
May 28, 2013·Immunity·Delphine GoubauCaetano Reis e Sousa
Jun 15, 2013·Veterinary Microbiology·Xiaying LiShijun J Zheng
Feb 21, 2014·Journal of Virology·Yijun DuJinbao Wang
Feb 1, 2015·Science·Siqi LiuZhijian J Chen
Citations
Dec 22, 2016·Viruses·Wendy Ullmer, Bert L Semler
Apr 14, 2017·Cell Death & Disease·Zixiang ZhuHaixue Zheng
Jun 2, 2017·Journal of Virology·Suhong QianPing Qian
Nov 1, 2016·Journal of Virology·Zixiang ZhuHaixue Zheng
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huisheng LiuHaixue Zheng
Jan 20, 2017·Cell Death & Disease·Xuxu FanShiqi Sun
Mar 22, 2019·Journal of Virology·Huisheng LiuHaixue Zheng
Apr 19, 2019·Journal of Virology·Wei ZhangHaixue Zheng
Sep 20, 2019·Journal of Virology·Dan LiHaixue Zheng
Jan 31, 2020·Journal of Virology·Wenping YangHaixue Zheng
Aug 29, 2018·Frontiers in Microbiology·Xiao-Xia MaXin Cao
Oct 16, 2018·Frontiers in Microbiology·Zixiang ZhuHaixue Zheng
Jul 31, 2019·Virologica Sinica·Qiao XueXuepeng Cai
Sep 10, 2020·Pathogens·Bo YangXiangtao Liu
Jul 6, 2019·Cell Death & Disease·Dan LiHaixue Zheng
Oct 1, 2020·Genes·Yanxue WangYuefeng Sun
Jul 1, 2017·Frontiers in Cellular and Infection Microbiology·Miguel Rodríguez Pulido, Margarita Sáiz
Aug 9, 2020·European Journal of Immunology·Xiangle ZhangHaixue Zheng
Dec 12, 2017·BioMed Research International·Huisheng LiuHaixue Zheng
Nov 30, 2018·Frontiers in Microbiology·Gisselle N MedinaTeresa de Los Santos
Sep 13, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiangle ZhangHaixue Zheng
Nov 25, 2020·PLoS Pathogens·Pathum EkanayakaJong-Soo Lee
Jan 6, 2021·Virologica Sinica·Huisheng LiuHaixue Zheng
Nov 10, 2020·Frontiers in Microbiology·Jiangling PengDan Li
Jan 26, 2021·Frontiers in Immunology·Junhong HaoXiangtao Liu
Feb 13, 2021·Cells·Hyejin KimYoung-Joon Ko
Dec 18, 2020·Journal of Virology·Yumei HanRuofei Feng
Dec 29, 2020·Journal of Virology·Keshan ZhangXiangtao Liu
Mar 18, 2021·The Journal of General Virology·Sonalika MahajanBramhadev Pattnaik
Mar 16, 2021·Frontiers in Immunology·Kangli LiHaixue Zheng
Jun 3, 2021·Viruses·Guoxiu LiJie Zhang
Jun 8, 2021·Frontiers in Immunology·Junyong GuanHuichen Guo
Jul 1, 2021·Journal of Virology·Huisheng LiuHaixue Zheng
Sep 16, 2021·Journal of Virology·Jing ZhangHaixue Zheng