The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-β signaling pathway

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Dan LiHong-Bing Shu

Abstract

Foot-and-mouth disease is a frequently occurring disease of cloven-hoofed animals that is caused by infection with the foot-and-mouth virus (FMDV). FMDV circumvents the type-I IFN response by expressing proteins that antagonize cellular innate immunity, such as leader protease and 3C protease. We identified the FMDV structural protein VP3 as a negative regulator of the virus-triggered IFN-β signaling pathway. Expression of FMDV VP3 inhibited the Sendai virus-triggered activation of IFN regulatory factor-3 and the expression of retinoic acid-inducible gene-I/melanoma differentiation-associated protein-5. Transient transfection and coimmunoprecipitation confirmed that the structural protein VP3 interacts with virus-induced signaling adapter (VISA), which is dependent on the C-terminal aa 111-220 of VP3. In addition, we found that FMDV VP3 inhibits the expression of VISA by disrupting its mRNA. Taken together, our findings reveal a novel strategy used by the structural VP3 protein of FMDV to evade host innate immunity.-Li, D., Yang, W., Yang, F., Liu, H., Zhu, Z., Lian, K., Lei, C., Li, S., Liu, X., Zheng, H., Shu, H. The VP3 structural protein of foot-and-mouth disease virus inhibits the IFN-β signaling pathway.

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Citations

Dec 22, 2016·Viruses·Wendy Ullmer, Bert L Semler
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Huisheng LiuHaixue Zheng
Aug 29, 2018·Frontiers in Microbiology·Xiao-Xia MaXin Cao
Jul 1, 2017·Frontiers in Cellular and Infection Microbiology·Miguel Rodríguez Pulido, Margarita Sáiz
Aug 9, 2020·European Journal of Immunology·Xiangle ZhangHaixue Zheng
Nov 30, 2018·Frontiers in Microbiology·Gisselle N MedinaTeresa de Los Santos
Sep 13, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiangle ZhangHaixue Zheng
Nov 10, 2020·Frontiers in Microbiology·Jiangling PengDan Li
Mar 18, 2021·The Journal of General Virology·Sonalika MahajanBramhadev Pattnaik
Mar 16, 2021·Frontiers in Immunology·Kangli LiHaixue Zheng

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