The vulnerability of the fetal sheep brain to hypoxemia at mid-gestation

Brain Research. Developmental Brain Research
S ReesR Harding

Abstract

Our aim was to test the hypothesis that a brief episode of hypoxemia near mid-gestation in fetal sheep will result in damage to the fetal brain with the extent and type of damage in any particular region being related to the developmental processes occurring at the time of the insult. Hypoxemia was induced, sufficient to reduce arterial O2 content by approximately 50%, by restricting utero-placental blood flow in 14 chronically catheterised fetuses for 6 h or 12 h at 84 days of gestation (term 145-8 days). Age-matched fetuses (n = 14; 4 operated and 10 unoperated) were used as controls. Fetuses were killed 7 days after being exposed to hypoxemia, and brains removed for histological analysis at the light and ultrastructural levels. Body weights of hypoxemic fetuses did not differ significantly from controls but brain weights were significantly reduced both in absolute terms and when expressed in relation to body weight (P < 0.05). Most fetuses exposed to hypoxemia sustained no gross brain damage. However, in one hypoxemic fetus from a multiple pregnancy there was extensive leucomalacia in the cortical white matter; mild focal damage was seen in another 8 hypoxemic fetuses. In the cerebral cortex (frontal lobe) the surface foldin...Continue Reading

References

Feb 1, 1977·Journal of Clinical Pathology. Supplement (Royal College of Pathologists)·A W Brown
Mar 1, 1979·Neuropathology and Applied Neurobiology·G H McIntoshB S Hetzel
Aug 1, 1976·Pediatric Clinics of North America·J J Volpe
Oct 1, 1992·Anatomy and Embryology·N R SaundersM L Reynolds
Nov 1, 1992·Journal of Neurobiology·D W Choi
Nov 1, 1992·American Journal of Obstetrics and Gynecology·E C MallardP D Gluckman
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·B T HopeS R Vincent
Oct 1, 1990·Early Human Development·A Leviton, N Paneth
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Jan 1, 1988·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S Rees, R Harding
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Dec 1, 1988·American Journal of Obstetrics and Gynecology·A D BockingB S Richardson
Dec 1, 1988·Journal of Applied Physiology·A D BockingS E White
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Apr 1, 1988·The Journal of Pediatrics·E Blair, F J Stanley
Aug 1, 1988·American Journal of Obstetrics and Gynecology·J F ClappL I Mann
Jun 1, 1986·American Journal of Obstetrics and Gynecology·R H PaulL Sipos
Jul 10, 1986·The New England Journal of Medicine·K B Nelson, J H Ellenberg
Dec 1, 1994·Cell and Tissue Research·M Kressel, P Groscurth
May 13, 1994·Brain Research. Developmental Brain Research·X X YanL S Jen
May 1, 1994·American Journal of Obstetrics and Gynecology·D H PenningB Richardson
Jan 1, 1994·American Journal of Obstetrics and Gynecology·E C MallardP D Gluckman
Jan 1, 1995·Reproduction, Fertility, and Development·G J McCrabb, R Harding
Oct 1, 1996·Clinical and Experimental Pharmacology & Physiology·G J McCrabb, R Harding
Aug 1, 1997·Neuropathology and Applied Neurobiology·R J Scott, L Hegyi

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Citations

Mar 9, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen A BackA Roger Hohimer
May 24, 2003·Brain Research. Developmental Brain Research·Mary TolcosSandra Rees
Jun 3, 2008·Behavioral Neuroscience·Timothy B JohnsonTimothy A Cudd
Oct 16, 2007·Cerebral Cortex·J DuboisP S Hüppi
Apr 25, 2012·Neurology Research International·Valerie BiranDonna M Ferriero
Dec 3, 2008·Pediatric Research·Michelle LoeligerSandra M Rees
Mar 17, 2009·Pediatric Research·Alan R BarnetteTerrie E Inder
Jan 16, 2010·AJNR. American Journal of Neuroradiology·Y ZhangT Jiang
Aug 31, 2013·AJNR. American Journal of Neuroradiology·H W ParkE A Kim
Aug 13, 2014·Veterinary Research Communications·Moustafa SalouciAnnick Gabriel
May 22, 2009·Journal of Neuropathology and Experimental Neurology·Sandra M ReesTerrie Inder
Feb 10, 2010·Journal of Neuropathology and Experimental Neurology·Sandra ReesRichard Harding
Nov 6, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Sandra ReesDavid Walker
Jan 10, 2012·Anatomia, histologia, embryologia·M SalouciA Gabriel
Apr 2, 2014·Glia·Stephen A Back, Paul A Rosenberg
Jun 30, 2005·Neuropsychologia·Shelli R KeslerLaura R Ment
Dec 28, 2002·Journal of Neuroscience Research·Paul A RosenbergJoseph J Volpe
Jun 30, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Stephen A Back
Jan 29, 2011·American Journal of Obstetrics and Gynecology·Yafeng DongCarl P Weiner
Nov 16, 2010·American Journal of Obstetrics and Gynecology·Sandra ReesTerrie Inder
Dec 19, 2012·Archives of Oral Biology·J L BainR B Johnson
Aug 3, 2001·Seminars in Neonatology : SN·E Saliba, S Marret
Jan 30, 2015·Journal of Korean Neurosurgical Society·Yoon Young ChungSeok Won Kim
Dec 3, 2014·Progress in Neurobiology·Qingyi Ma, Lubo Zhang
May 11, 2016·Seminars in Fetal & Neonatal Medicine·Christopher R Pierson, Fahd Al Sufiani
Jun 12, 2016·Physiology & Behavior·Damien S HunterKathryn L Gatford
Apr 30, 2008·The Annals of Thoracic Surgery·Christopher T LamPirooz Eghtesady
Nov 2, 2016·Pediatric Research·Nathalie H P ClaessensMichael von Rhein
Jan 19, 2006·Journal of Child Neurology·Terrie InderSandra Rees

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