The wake maintenance zone shows task dependent changes in cognitive function following one night without sleep

Sleep
William R McMahonClare Anderson

Abstract

The interaction between homeostatic sleep pressure and circadian timing modulates the impact of sleep deprivation on cognition. We aimed to investigate how this interaction affects different cognitive functions. Twenty-three healthy volunteers (18 males; mean age = 25.4 ± 5.7 years) underwent 40 hours of sleep deprivation under constant routine conditions. Performance on the Psychomotor Vigilance Test and a cognitive battery assessing vigilant attention, complex attention, recognition memory, and working memory was assessed in the morning (27 hours awake) and evening (37 hours awake) during sleep deprivation and compared to well-rested performance 24 hours earlier. Circadian phase assessments confirmed evening tests occurred in the wake maintenance zone (WMZ). Increased time awake significantly impacted performance on all measures except recognition memory. Post hoc analyses found performance on all measures was significantly impaired in the morning following 27 hours of sleep deprivation compared to well-rested performance 24 hours earlier. In contrast, complex attention and working memory were preserved in the WMZ after 37 hours awake compared to 24 hours earlier, while vigilant attention and PVT performance were significantl...Continue Reading

Associated Clinical Trials

References

May 1, 1990·The International Journal of Neuroscience·T Akerstedt, M Gillberg
May 1, 1986·Electroencephalography and Clinical Neurophysiology·P Lavie
Jan 1, 1989·Chronobiology International·A J Lewy, R L Sack
Sep 21, 1996·BMJ : British Medical Journal·J M Bland, D G Altman
Jul 17, 1997·Nature·D Dawson, K Reid
Nov 5, 1997·Journal of Biological Rhythms·A VoultsiosD Dawson
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·D J Kennaway, A Voultsios
May 20, 1998·International Journal of Legal Medicine·L A Reyner, J A Horne
Jun 26, 2001·Journal of Sleep Research·S P DrummondG G Brown
Oct 5, 2001·Lancet·S M Rajaratnam, J Arendt
Oct 24, 2001·Journal of Biological Rhythms·M DumontJ Paquet
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S P Drummond, G G Brown
Feb 12, 2002·Journal of Biological Rhythms·Jeanne F Duffy, Derk-Jan Dijk
Sep 3, 2003·Psychiatry and Clinical Neurosciences·Heon-Jeong LeeKwang-Yoon Suh
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael W L Chee, Wei Chieh Choo
Mar 18, 2005·Menopause : the Journal of the North American Menopause Society·Paula AlholaPäivi Polo-Kantola
Apr 19, 2005·Journal of Biological Rhythms·Kenneth P WrightCharles A Czeisler
Nov 3, 2005·Psychiatry Research·Sean P A DrummondGregory G Brown
May 25, 2006·British Journal of Sports Medicine·P MaruffD Darby
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Y M Lisa ChuahMichael W L Chee
Aug 17, 2006·Journal of Sleep Research·Sean P A DrummondSusan F Tapert
Apr 28, 2009·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Paul MaruffRobert H Pietrzak
Sep 19, 2009·NeuroImage·Michael W L CheeVitali Zagorodnov
Oct 21, 2009·Journal of Sleep Research·Clare Anderson, David L Dickinson
Dec 8, 2009·Sleep Medicine Reviews·Julia A ShekletonShantha M W Rajaratnam
May 5, 2010·Psychological Bulletin·Julian Lim, David F Dinges
Oct 5, 2010·Behavioural Brain Research·Clare Anderson, Charlotte R Platten
Dec 29, 2010·Frontiers in Neurology·Tracey L SlettenShantha M W Rajaratnam
Jun 4, 2011·American Journal of Alzheimer's Disease and Other Dementias·Dustin HammersBruno Giordani
Mar 13, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David G DarbyPaul Maruff
Sep 11, 2012·Accident; Analysis and Prevention·Melissa A St HilaireElizabeth B Klerman
Apr 16, 2013·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Julia A ShekletonSteven W Lockley
May 13, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Andrea G LoueyPaul Mccrory

❮ Previous
Next ❯

Citations

Jun 12, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Cameron H GoodVincent Mysliwiec

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.