The weanling male rat as an assay for endocrine disruption: preliminary observations

Regulatory Toxicology and Pharmacology : RTP
J Ashby, P A Lefevre

Abstract

Kelce and Wilson (J. Mol. Med. 75, 198-207, 1997) have suggested that dosing chemicals to newly weaned male rats for 1 month may yield a useful assay for antiandrogens. This suggestion was supported by reference to unpublished data on the antiandrogen vinclozolin which indicated reductions in the weight of accessory sex organs. The necessity for dosing during the full approximately 30 days of the protocol was not justified. An evaluation of this protocol has commenced by the dosing of vinclozolin, cyproterone acetate, and anastrozole daily to newly weaned male rats for 3, 7, or 14 days. No changes were observed in accessory sex organs when vinclozolin or anastrozole was dosed for 3 days. Significant changes were observed in the absolute and relative weight of all of the sex accessory organs for rats dosed for 7 or 14 days with cyproterone acetate. The effects produced by vinclozolin and anastrozole when dosed for 7 or 14 days varied according to the duration of exposure with the main effects on the accessory sex organs being seen after 14 days of dosing. The effects produced after 7 days of dosing with vinclozolin or anastrozole in arachis oil had resolved 10 days after the last of the seven doses. Data are presented using eith...Continue Reading

References

Jan 1, 1987·Mutation Research·J Ashby
Dec 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J R ReelB H Neal

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Citations

Aug 5, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherry A FergusonJordan S Abshire
Mar 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jinyan CaoHeather B Patisaul
Oct 25, 2001·Environmental Health Perspectives·E Baatrup, M Junge
Jul 5, 2006·Environmental Health Perspectives·Ioanna KatsiadakiAlexander Pickering Scott
May 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sherry A FergusonGrace E Kissling
Oct 9, 2012·Neurotoxicology and Teratology·Sherry A FergusonJordan S Abshire
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·S A Clode
Jun 22, 2000·Toxicologic Pathology·M J Iatropoulos
Dec 12, 2003·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·C NellemannJ Ashby
Jan 19, 2010·Journal of Applied Toxicology : JAT·Hyun-Ju MoonSoon Young Han
Jun 19, 2001·Journal of Applied Toxicology : JAT·P SohoniJ P Sumpter
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gokul Krishna, Muralidhara
Feb 15, 2008·Pediatrics·Mari S GolubJorma Toppari

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