The weight of nutrients: kynurenine metabolites in obesity and exercise

Journal of Internal Medicine
S DadvarJorge L Ruas

Abstract

Obesity ultimately results from an imbalance between energy intake and expenditure. However, in addition to their bioenergetic value, nutrients and their metabolites can function as important signalling molecules in energy homeostasis. Indeed, macronutrients and their metabolites can be direct regulators of metabolism through their actions on different organs. In turn, target organs can decide to use, store or transform the incoming nutrients depending on their physiological context and in coordination with other cell types. Tryptophan-kynurenine metabolites are an example of a family of compounds that can serve as systemic integrators of energy metabolism by signalling to different cell types. These include adipocytes, immune cells and muscle fibres, in addition to the well-known effects of kynurenine metabolites on the central nervous system. In the context of energy metabolism, several of the effects elicited by kynurenic acid are mediated by the G-protein-coupled receptor, GPR35. As GPR35 is expressed in tissues such as the adipose tissue, immune cells and the gastrointestinal tract, this receptor could be a potential therapeutic target for the treatment of obesity, diabetes and other metabolic diseases. In addition, metabo...Continue Reading

References

Jul 1, 1971·The American Journal of Clinical Nutrition·Y Kotake, E Murakami
Feb 13, 1984·FEBS Letters·P YoungM Ashwell
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·J L van de Kamp, A Smolen
Feb 28, 1998·Genomics·B F O'DowdS R George
Apr 15, 2000·Nature·P G Kopelman
Apr 15, 2000·Nature·B B Lowell, B M Spiegelman
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L F MichaelB M Spiegelman
Oct 3, 2001·The Journal of Biological Chemistry·A S GreenbergF B Kraemer
Sep 7, 2002·Molecular and Cellular Biology·Peichuan ZhangDouglas R Cavener
Jul 10, 2003·Immunology and Cell Biology·John R Moffett, Ma Aryan Namboodiri
Sep 5, 2003·American Journal of Physiology. Endocrinology and Metabolism·J G GrannemanL A Schwamb
Sep 1, 1962·Journal of Biochemistry·N OGASAWARAY KOTAKE
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Jan 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yumei XiongMasashi Yanagisawa
Dec 28, 2004·Nature Medicine·Akira HirasawaGozoh Tsujimoto
Feb 11, 2005·Nature Reviews. Genetics·Christopher G BellPhilippe Froguel
Jun 3, 2005·The Journal of Biological Chemistry·Andrew K P TaggartM Gerard Waters
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Katharina SchröcksnadelDietmar Fuchs
Oct 8, 2005·Pflügers Archiv : European journal of physiology·Ana M Pajor
Apr 29, 2006·Neuroscience Letters·Christina PrescottKathryn M Partin
Jun 7, 2006·The Journal of Biological Chemistry·Jinghong WangLei Ling
Aug 18, 2006·The Journal of Biological Chemistry·Jozef UkropecLeslie P Kozak
Nov 13, 2007·Biochemical and Biophysical Research Communications·Hiroyuki OhshiroKatsuomi Ichikawa
Sep 9, 2008·European Heart Journal·Gideon R HajerFrank L J Visseren

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Citations

Jun 15, 2019·Metabolomics : Official Journal of the Metabolomic Society·Oscar Daniel Rangel-HuertaAngel Gil
Aug 25, 2018·Journal of Internal Medicine·A Vidal-Puig, S Enerback
Apr 14, 2019·Molecular Psychiatry·Jonathan Savitz
Sep 21, 2019·The Journal of Infectious Diseases·Marco GelpiUNKNOWN Copenhagen Comorbidity in HIV Infection (COCOMO) Study
Aug 15, 2020·Frontiers in Immunology·Flaminia BardanzelluVassilios Fanos
Jul 29, 2020·Journal of Clinical Medicine·Yeongkeun KwonSungsoo Park
Dec 30, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A V ShestopalovS A Rumyantsev
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jiayu YeDeanna L Gibson
May 26, 2021·Journal of Psychiatric Research·Ping ZhangYunlong Tan
Jun 11, 2021·Expert Review of Proteomics·Flaminia BardanzelluVassilios Fanos

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