The well-balanced nucleoside-nucleotide mixture "OG-VI" for special medical purposes

Nutrition
Y IwasaS Ogoshi

Abstract

Nucleotides and nucleosides are essential components in all cells. However, nucleotides have not been supplied in parenteral nutrition regimens. We developed a well-balanced nucleoside-nucleotide mixture "OG-VI" and examined its effect in animals under some stressed conditions. OG-VI was composed of 30 mmol/l of inosine, 30 mmol/l of guanosine monophosphate, 30 mmol/l of cytidine, 22.5 mmol/l of uridine and 7.4 mmol/l of thymidine. The whole body protein turnover increased significantly in rats receiving total parenteral nutrition (TPN) with OG-VI solution after 70% hepatectomy, compared with rats receiving normal TPN without OG-VI (122.1 +/- 20.9 mgN.kg-1.h-1 vs. 97.4 +/- 10.1 mgN.kg-1.h-1, P < 0.01, n = 10). OG-VI significantly enhanced protein synthesis while it did not decrease protein breakdown. The effect of OG-VI on myocardium after hypoxic challenge was also examined in rats. The creatine phosphate (PCr)/inorganic phosphate (Pi) was decreased in normal rat myocardium after hypoxic challenge. However, in the rats administered OG-VI, PCr/Pi was maintained at baseline level and did not decrease after hypoxia. There was no significant change in the level of adenosine triphosphate (ATP) between before and after hypoxic chall...Continue Reading

References

May 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·S OgoshiT Tamiya
Sep 1, 1983·Transplantation·C T Van BurenF B Rudolph

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Citations

Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·M J Rennie
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·F B Rudolph, C T Van Buren
Jun 30, 2018·Current Developments in Nutrition·Martha S FieldPatrick J Stover
Jul 23, 2019·Luminescence : the Journal of Biological and Chemical Luminescence·Hua-Xin ZhangQing-Hua Xia

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