The Wellcome Foundation Lecture, 1980: monoclonal antibodies from hybrid myelomas

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
C Milstein

Abstract

When the lymphoid cells from immunized animals are fused with myeloma cells adapted to grow permanently in culture, hybrid cells can be isolated that are capable of permanent growth in culture, or as transplantable myeloma tumour in animals, and that at the same time express the antibodies of the immunized donor. Such hybrid cells can be cloned and the antibody produced by each clone is monoclonal. By this procedure therefore it is possible to dissect the heterogeneous immune response of an animal. The monoclonal antibodies can be permanently produced in unlimited quantities and the products are well defined chemical entities, unlike antibodies prepared in animals, which vary from animal to animal and even in different periods within a single animal. These properties have been of great importance in the use of antibodies as biochemical reagents in basic research in a variety of fields. They are also replacing conventional antibodies in standard laboratory practice.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R Levy, J Dilley
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H HengartnerE Müller
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Mar 1, 1979·European Journal of Immunology·A J McMichaelC Milstein
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A C CuelloC Milstein
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·C MilsteinC D Wilde
Jul 1, 1976·European Journal of Immunology·G Köhler, C Milstein
Jan 1, 1970·Progress in Biophysics and Molecular Biology·C Milstein, J R Pink
Jun 1, 1980·Molecular Immunology·M UotilaE Ruoslahti
Apr 3, 1980·Nature·K F BradstockC Milstein
Jul 1, 1980·European Journal of Immunology·E L ReinherzS F Schlossman
Oct 1, 1981·British Journal of Haematology·D H CrawfordG Goldstein

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Citations

Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Milstein
Apr 1, 1989·Journal of Pharmaceutical Sciences·J J BerghP L Wessels
Nov 1, 1985·Archives of Biochemistry and Biophysics·L M ReikP E Thomas
Oct 1, 1988·Experimental Eye Research·T TsujiH Fujisawa
Feb 22, 1990·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·C Milstein
Apr 1, 1985·Journal of Dental Research·J E Aubin

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