PMID: 9437275Jan 23, 1998Paper

The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin

BMJ : British Medical Journal
J CaroJ Shepherd

Abstract

To estimate the economic efficiency of using pravastatin to prevent the transition from health to cardiovascular disease in men with hypercholesterolaemia. Economic benefit analysis based on data from the West of Scotland coronary prevention study. Treatment specific hazards of developing cardiovascular disease according to various definitions were estimated. Scottish record linkage data provided disease specific survival. Cost estimates were based on extracontractual tariffs and event specific average lengths of stay calculated from the West of Scotland coronary prevention study. Men with hypercholesterolaemia similar to the subjects in the West of Scotland coronary prevention study. Cost consequences, the number of transitions from health to cardiovascular disease prevented, the number needed to start treatment, and cost per life year gained. If 10,000 of these men started taking pravastatin, 318 of them would not make the transition from health to cardiovascular disease (number needed to treat, 31.4), at a net discounted cost of 20m Pounds over 5 years. These benefits imply an undiscounted gain of 2,460 years of life, and thus 8121 Pounds per life year gained, or 20,375 Pounds per life year gained if benefits are discounted....Continue Reading

Citations

Apr 30, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Peter Lindgren, Bengt Jönsson
Jun 17, 2006·Cardiovascular Drugs and Therapy·Paul A Scuffham, József Kósa
Jun 24, 2004·Current Treatment Options in Cardiovascular Medicine·William S. Weintraub
Mar 27, 2001·Transplantation Proceedings·B A Kiberd, K A West
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Oct 12, 2007·The New England Journal of Medicine·Ian FordUNKNOWN West of Scotland Coronary Prevention Study Group
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