The White Collar protein WcoA of Fusarium fujikuroi is not essential for photocarotenogenesis, but is involved in the regulation of secondary metabolism and conidiation

Fungal Genetics and Biology : FG & B
Alejandro F Estrada, Javier Avalos

Abstract

The fungal proteins of the White Collar photoreceptor family, represented by WC-1 from Neurospora crassa, mediate the control by light of different biochemical and developmental processes, such as carotenogenesis or sporulation. Carotenoid biosynthesis is induced by light in the gibberellin-producing fungus Fusarium fujikuroi. In an attempt to identify the photoreceptor for this response, we cloned the only WC-1-like gene present in the available Fusarium genomes, that we called wcoA. The predicted WcoA polypeptide is highly similar to WC-1 and contains the relevant functional domains of this protein. In contrast to the Neurospora counterpart, wcoA expression is not affected by light. Unexpectedly, targeted wcoA disruptant strains maintain the light-induced carotenogenesis. Furthermore, the wcoA mutants show a drastic reduction of fusarin production in the light, and produce less gibberellins and more bikaverins than the parental strain under nitrogen-limiting conditions. The changes in the production of the different products indicate a key regulatory role for WcoA in secondary metabolism of this fungus. Additionally, the mutants are severely affected in conidiation rates under different culture conditions, indicating a more g...Continue Reading

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Citations

Nov 17, 2009·Applied Microbiology and Biotechnology·Doris Tisch, Monika Schmoll
Apr 9, 2010·Applied Microbiology and Biotechnology·M Carmen LimónJavier Avalos
Apr 1, 2010·Current Genetics·Bruno Giuliano Garisto DonzelliDonna M Gibson
Apr 2, 2013·Molecular Genetics and Genomics : MGG·Roberto Rodríguez-OrtizJavier Avalos
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Aug 7, 2012·Applied and Environmental Microbiology·Violeta Díaz-SánchezM Carmen Limón
Feb 19, 2013·Applied and Environmental Microbiology·Marta CastrilloJavier Avalos
Aug 26, 2014·Fungal Genetics and Biology : FG & B·Marta Castrillo, Javier Avalos
Sep 17, 2015·Environmental Microbiology·Arko DasguptaJennifer J Loros
Jan 30, 2013·Fungal Genetics and Biology : FG & B·Eusebio NavarroVictoriano Garre
Dec 6, 2011·International Journal of Food Microbiology·Francesca FanelliGiuseppina Mulè
Oct 20, 2015·Applied Microbiology and Biotechnology·Tao YangCaihong Dong
Apr 14, 2009·Journal of Molecular Biology·Alejandro F Estrada, Javier Avalos
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Oct 7, 2014·Current Genetics·Javier Avalos, M Carmen Limón
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Jul 4, 2012·Fungal Genetics and Biology : FG & B·Roberto Rodríguez-OrtizJavier Avalos
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May 13, 2010·Fungal Genetics and Biology : FG & B·Javier Avalos, Alejandro F Estrada
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Feb 9, 2020·Applied and Environmental Microbiology·Wei LuoXiaobin Yu
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Sep 29, 2017·Fungal biology and biotechnology·Rebecca GmoserMohammad J Taherzadeh
Jan 22, 2020·Scientific Reports·Obdulia Parra-RiveroJavier Avalos

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