PMID: 15371930Sep 17, 2004Paper

The wide spectrum of steatohepatitis: a report of four cases and a review of the literature

European Journal of Gastroenterology & Hepatology
A LonardoPaola Loria

Abstract

We report on four cases displaying the wide range of aetiological risk factors (presence or absence of family history of dyslipidaemia and cryptogenic cirrhosis, from subnormal body mass index through morbid obesity, from absent through hepatotoxic alcohol consumption), laboratory test results (from subnormal through elevated uric acid and ferritin values), ultrasonographic changes (from normal findings through 'bright liver' with or without attenuation of ultrasound beam and absence/presence of focal lesions), and histological severity of steatohepatitis (fibrosis appearing to be inversely related to the amount of liver fat but zone 3 accentuation of lesions and ballooning being observed in all cases). Cases illustrate the concepts of overlapping aetiologies of steatohepatitis (hepatitis C, diabetes and lipodystrophy); the relationships between cryptogenic cirrhosis, familial cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma; familial hypobetalipoproteinaemia as an aetiology of steatohepatitis; and alcoholic liver disease in the obese. These issues, which are worthy of future investigation, are reviewed.

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Citations

Jul 18, 2008·Internal and Emergency Medicine·Stefano BallestriPaola Loria
Mar 1, 2006·Seminars in Interventional Radiology·Ashwin AnanthakrishnanKia Saeian
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·A LonardoP Loria
May 24, 2011·Clinics and Research in Hepatology and Gastroenterology·Jason Y K YapEve A Roberts
Mar 12, 2009·The American Journal of Gastroenterology·Amedeo Lonardo, Paola Loria
Dec 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stefano BallestriPaola Loria
Nov 1, 2017·World Journal of Gastroenterology : WJG·Amedeo LonardoLuigi Elio Adinolfi

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