The winged-helix transcription factor Trident is expressed in actively dividing lymphocytes

Immunobiology
W KorverH Clevers

Abstract

We recently identified the winged-helix transcription factor Trident and described its expression pattern in synchronized fibroblasts. We have now studied Trident expression in cell lines, differentiating thymocytes and in lymphocytes derived from peripheral blood. During T cell differentiation, expression peaked in the actively dividing immature single positive cells. In peripheral blood lymphocytes, expression of Trident mRNA was absent, but could be induced upon stimulation with mitogens in vitro. These observations imply a function for Trident in dividing lymphocytes.

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Citations

Feb 7, 2013·Journal of Molecular Neuroscience : MN·Shuangwei ZhangChunwu Zhang
Jan 18, 2005·Nature Cell Biology·Jamila LaoukiliRené H Medema
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Jun 29, 2018·Proceedings of the National Academy of Sciences of the United States of America·M C GageI Pineda-Torra

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