The Wistar Audiogenic Rat (WAR) strain and its contributions to epileptology and related comorbidities: History and perspectives

Epilepsy & Behavior : E&B
Norberto Garcia-CairascoJosé A Cortes de Oliveira

Abstract

In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar Audiogenic Rat (WAR), first introduced to the neuroscience international community more than 25years ago. The WAR strain is a genetically selected reflex model susceptible to audiogenic seizures (AS), acutely mimicking brainstem-dependent tonic-clonic seizures and chronically (by audiogenic kindling), temporal lobe epilepsy (TLE). Seminal neuroethological, electrophysiological, cellular, and molecular protocols support the WAR strain as a suitable and reliable animal model to study the complexity and emergent functions typical of epileptogenic networks. Furthermore, since epilepsy comorbidities have emerged as a hot topic in epilepsy research, we discuss the use of WARs in fields such as neuropsychiatry, memory and learning, neuroplasticity, neuroendocrinology, and cardio-respiratory autonomic regulation. Last, but not least, we propose that this strain be used in "omics" studies, as well as with the most advanced molecular and computational modeling techniques. Collectively, pioneering and recent findings reinforce the complexity associated with WAR alterations, consequent to the combination of their genetically-dependent background an...Continue Reading

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Citations

May 21, 2018·The European Journal of Neuroscience·Alexandra Olimpio Siqueira CunhaRicardo Maurício Leão
Jun 22, 2018·Systems Biology in Reproductive Medicine·Eduardo H UmeokaPaula A Navarro
Dec 6, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carlos Roberto Porto DechandtLuciane Carla Alberici
Mar 14, 2020·PloS One·Elena Díaz-CasadoDolores E López
Oct 22, 2019·Frontiers in Neurology·Carlos Roberto Porto DechandtLuciane Carla Alberici
Jun 13, 2020·Frontiers in Neuroscience·Sandra M Díaz-RodríguezDolores E Lopéz
Jul 24, 2018·Frontiers in Behavioral Neuroscience·Lívea Dornela GodoyEduardo Henrique de Lima Umeoka
May 19, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·S A KrivopalovK N Zabegalov
Apr 15, 2020·International Journal of Neural Systems·Rodrigo F O PenaAlexandra Olimpio Siqueira Cunha
Jan 8, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Jan 20, 2020·Neuroscience and Biobehavioral Reviews·Willian Lazarini-LopesNorberto Garcia-Cairasco
May 21, 2020·Brain Research Bulletin·Octávio A C MaiaThiago S Moreira
Nov 7, 2019·Epilepsy & Behavior : E&B·José Ramón BosqueDolores E López
Jan 12, 2021·Frontiers in Neuroscience·Christiane BecariMarilia G A G Pereira
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Willian Lazarini-LopesNorberto Garcia-Cairasco
Apr 13, 2021·Frontiers in Behavioral Neuroscience·Alejando Fuerte-HortigónDolores E López
Apr 23, 2021·Epilepsy & Behavior : E&B·Willian Lazarini-LopesNorberto Garcia-Cairasco
Jun 29, 2021·Frontiers in Neurology·Samara DamascenoAna Lúcia Brunialti Godard

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