The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours

The Journal of Pathology
E J SawyerI P M Tomlinson

Abstract

In a previous study of phyllodes tumours, it has been shown that both the stroma and the epithelium can exhibit distinct molecular changes, suggesting that both are part of the neoplastic process. In view of this finding, it was decided to study stromal-epithelial interactions in these tumours by examining the Wnt-APC-beta-catenin pathway. Beta-catenin and cyclin D1 immunohistochemistry was performed on 119 phyllodes tumours. Eighty-six (72%) showed stromal nuclear beta-catenin localization and in 57% the staining was moderate or strong; however, of the eight malignant tumours in the series, seven showed absent or weak nuclear staining (p<0.025). In no tumour was nuclear beta-catenin staining seen in the epithelial component. Moderate or strong stromal cyclin D1 staining correlated with nuclear stromal beta-catenin staining (p<0.05). Forty-five of the tumours, including two malignant lesions, were screened for beta-catenin exon 3 mutations using SSCP and sequencing, but none was found. Loss of heterozygosity (LOH) of the marker D5S346 was used to infer APC mutation, but only one (benign) tumour showed LOH. Wnt2 and Wnt5a mRNA was localized by in situ hybridization in 13 cases (three malignant) chosen to reflect the different be...Continue Reading

References

Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·A de La CosteC Perret
Mar 5, 1999·Breast Cancer Research and Treatment·D M Barnes, C E Gillett
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Oct 8, 1999·Molecular Biology of the Cell·M W KlymkowskyY E Vourgourakis
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P J Morin
Mar 7, 2000·The American Journal of Pathology·E J SawyerI P Tomlinson
Mar 17, 2000·International Journal of Cancer. Journal International Du Cancer·T UtsumiN Harada
Mar 31, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M JönssonT Andersson
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Y LinM C Hung
Jun 30, 2000·Carcinogenesis·P W SchlosshauerJ Kitajewski

❮ Previous
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Citations

Dec 19, 2007·Surgery Today·Rin YamaguchiMasamichi Kojiro
Jun 22, 2010·Breast Cancer Research and Treatment·Katie T HuangStephen B Fox
Jul 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dinesh RakhejaArthur G Weinberg
Aug 10, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Magali Lacroix-TrikiJorge S Reis-Filho
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marick LaéJérôme Couturier
Aug 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wedad HannaAbha Malik
Feb 25, 2006·Pathology International·Teppei MorikawaMasashi Fukayama
Feb 14, 2013·Journal of Clinical Pathology·Rooshdiya Z KarimCheok Soon Lee
Oct 21, 2005·Cell Communication and Signaling : CCS·Rajeeb Kumar SwainHerbert Steinbeisser
Nov 12, 2010·Breast Cancer Research : BCR·Angela IncassatiPamela Cowin
Jun 29, 2005·American Journal of Clinical Pathology·Arno KuijperPaul J van Diest
Mar 4, 2005·American Journal of Clinical Pathology·Puay-Hoon TanBoon-Huat Bay
Dec 15, 2010·Pathology Research International·Alessandra GurreraGaetano Magro
Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Haiyan Liu
Jul 26, 2006·World Journal of Surgery·Shih-Ping ChengChien-Liang Liu
Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan
Jul 24, 2012·Human Pathology·Julia Y S TsangGary M Tse
Feb 23, 2011·The Journal of Pathology·Cecilia LaiAndrew Silver
Jun 19, 2004·Pathology·Rooshdiya KarimSoon Lee
Jun 10, 2015·Journal of Clinical Pathology·John TawasilGary M Tse
Apr 4, 2015·British Journal of Cancer·M YoshidaA Ochiai
Feb 14, 2015·Breast Cancer Research and Treatment·Jeffrey Chun Tatt LimPuay Hoon Tan
Jul 21, 2004·Cancer Cell·Minna AllinenKornelia Polyak
Jun 4, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Su-Yang LiuGregor Krings
Jun 13, 2016·Breast Cancer Research and Treatment·Yanhong ZhangCelina G Kleer
Jul 1, 2016·Archives of Pathology & Laboratory Medicine·Yanhong Zhang, Celina G Kleer
Aug 30, 2016·Cancers·Marwa S AsemM Sharon Stack
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cheng-Long HuangMasaki Ueno
Mar 8, 2017·Molecular Oncology·Felipe C GeyerBritta Weigelt
Oct 1, 2005·Pathology·See Ming Lim, Puay Hoon Tan
Jun 24, 2004·Toxicologic Pathology·Robert D CardiffJeffrey P Gregg
Feb 7, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jun SunJames L Madara
Feb 21, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Michiyo SaimuraSadafumi Tamiya
Apr 15, 2003·The Journal of Pathology·Elinor J SawyerAndrew M Hanby

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