The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling

The Journal of Investigative Dermatology
Ryan F L O'ShaughnessyA M Christiano

Abstract

We used microarray hybridization to identify genes induced in the dermal papilla (DP) during anagen as a result of the interaction with epithelial matrix cells. We identified inhibitors of the bone morphogenetic protein (BMP) and transforming growth factor beta (TGFbeta)-signalling pathway, as well as the rat homologue of the Xenopus-secreted WNT modulator Wise. A large number of genes previously determined to be expressed in the DP were shown to be expressed in both the DP and dermal sheath (DS). Genes induced in the DP during anagen included modulators of genes expressed additionally in the DS as well as specialized extracellular matrix components. Expression of some of these genes were lost when the DP cells were cultured, suggesting that their expression was interaction dependent. One such gene, the WNT-signalling modulator Wise, was expressed in the DP and not in the non-inductive DS and was additionally expressed at high levels in the precortex and in the putative bulge region. In addition to the reported WNT-signalling modulation role, we show that Wise reduced both BMP and TGFbeta signalling in transformed fibroblasts. We speculate that loss of gene expression in cultured cells is a model for the loss of gene expression...Continue Reading

References

Jul 12, 1991·Science·B BlumbergK W Cho
Sep 1, 1995·The Journal of Investigative Dermatology·D L du CrosJ R Couchman
Apr 1, 1997·Matrix Biology : Journal of the International Society for Matrix Biology·D J HulmesE Kessler
Dec 24, 1997·The Journal of Investigative Dermatology·S M RudmanT Kealey
Mar 14, 1998·Developmental Biology·C M Jones, J C Smith
Jan 20, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·T Matsuzaki, K Yoshizato
Feb 17, 1999·The Journal of Dermatology·R Paus
Feb 26, 1999·Leukemia & Lymphoma·K Oritani, P W Kincade
Nov 13, 1999·Nature Cell Biology·V A BotchkarevR Paus
Apr 1, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K FoitzikR Paus
Oct 14, 2000·Genomics·M A SleemanJ D Watson
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Silvia MarettoStefano Piccolo
Aug 6, 2003·Development·Nobue ItasakiRobb Krumlauf

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Citations

Apr 16, 2010·Nature·Yutaka ShimomuraAngela M Christiano
Jun 26, 2009·The Journal of Biological Chemistry·Katherine B LinternNobue Itasaki
Mar 25, 2006·Future Oncology·Yonghe Li, Guojun Bu
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrey A SharovVladimir A Botchkarev
Apr 6, 2013·Journal of Dermatological Science·Manabu Ohyama, Ophelia Veraitch
Jul 28, 2007·The Journal of Investigative Dermatology·Maud-Virginie Brancaz-BouvierStefan Nonchev
Sep 24, 2008·Experimental Gerontology·Christos C ZouboulisCatherin Niemann
Jun 20, 2007·European Journal of Cell Biology·Stephan TiedeRalf Paus
Sep 28, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Debra L ElliesRobb Krumlauf
Jan 24, 2007·The European Journal of Neuroscience·Jeannette HenningUlrike Gimsa
Apr 18, 2012·Developmental Biology·Katja NärhiMarja L Mikkola
Sep 4, 2007·Developmental Biology·Sonia Guidato, Nobue Itasaki
Apr 26, 2016·The Journal of Investigative Dermatology·Andrew A SmithJill A Helms
Jun 14, 2005·Cytokine & Growth Factor Reviews·Motoko Yanagita
Oct 28, 2018·The British Journal of Dermatology·I I BadshahR F L O'Shaughnessy
Aug 26, 2006·Stem Cells·Yao Fei HuMaya Sieber-Blum
Jul 27, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y Shigetani, N Itasaki
Aug 1, 2006·Endocrine Reviews·Ulrich OhnemusRalf Paus
May 25, 2012·Journal of Cell Science·Manabu OhyamaMasayuki Amagai
Dec 18, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liang LiuAngela M Christiano
May 24, 2005·The Journal of Biological Chemistry·Mikhail SemënovXi He

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