The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling.

Developmental Cell
Monica CoradaElisabetta Dejana

Abstract

The Wnt/beta-catenin pathway is evolutionary conserved signaling system that regulates cell differentiation and organogenesis. We show that endothelial specific stabilization of Wnt/beta-catenin signaling alters early vascular development in the embryo. The phenotype resembles that induced by upregulation of Notch signaling, including lack of vascular remodeling, altered elongation of the intersomitic vessels, defects in branching, and loss of venous identity. Both in vivo and in vitro data show that beta-catenin upregulates Dll4 transcription and strongly increases Notch signaling in the endothelium, leading to functional and morphological alterations. The functional consequences of beta-catenin signaling depend on the stage of vascular development and are lost when a gain-of-function mutation is induced at a late stage of development or postnatally. Our findings establish a link between Wnt and Notch signaling in vascular development. We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification.

References

Aug 1, 1992·Current Opinion in Genetics & Development·M E Dickinson, A P McMahon
Apr 30, 1999·Science·S Artavanis-TsakonasR J Lake
Feb 13, 2001·Developmental Biology·Y Y KisanukiM Yanagisawa
Jan 29, 2003·Angiogenesis·A M Goodwin, P A D'Amore
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Silvia MarettoStefano Piccolo
Jan 22, 2004·The Biochemical Journal·Thilo HagenAntonio Vidal-Puig
Jan 25, 2005·Nature Immunology·Andrew W DuncanTannishtha Reya
Jul 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Timothy R CarlsonRong Wang
Aug 16, 2005·Current Opinion in Cell Biology·Dirk JunghansRolf Kemler
Feb 2, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jackelyn A AlvaM Luisa Iruela-Arispe
Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Steven SuchtingAnne Eichmann
Mar 6, 2007·Developmental Cell·Joaquín Grego-BessaJosé Luis de la Pompa
Apr 26, 2007·Nature Reviews. Cancer·Gavin ThurstonGeorge D Yancopoulos
May 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shuichi UenoCharles E Murry
Jun 9, 2007·Circulation Research·Jennifer J Hofmann, M Luisa Iruela-Arispe
Oct 17, 2007·Genes & Development·Cristina Roca, Ralf H Adams
Apr 25, 2008·Nature Reviews. Cancer·Alexandra Klaus, Walter Birchmeier
Aug 5, 2008·Current Drug Targets·Nancy L Parmalee, Jan Kitajewski
Oct 29, 2008·The Journal of Cell Biology·Stefan LiebnerElisabetta Dejana
Jan 9, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard DanemanBen A Barres
Feb 17, 2009·Developmental Cell·L-K Phng, Holger Gerhardt
Jun 19, 2009·Nature Reviews. Molecular Cell Biology·Stephane Angers, Randall T Moon
Jan 19, 2010·Development·Guillermo Oliver, R Sathish Srinivasan

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Citations

Oct 25, 2013·Nature Communications·Monica CoradaElisabetta Dejana
Aug 24, 2011·Nature Reviews. Molecular Cell Biology·Shane P Herbert, Didier Y R Stainier
Jan 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Courtney T GriffinTerry Magnuson
Feb 1, 2012·Molecular and Cellular Biology·Carol D Curtis, Courtney T Griffin
Nov 23, 2011·Journal of Experimental & Clinical Cancer Research : CR·Song-Bing HeXing-Guo Zhu
Sep 20, 2011·Vascular Cell·Frank KuhnertGavin Thurston
Sep 4, 2012·Vascular Cell·Andrew C Newman, Christopher C W Hughes
Oct 19, 2011·Development·Aniket V GoreBrant M Weinstein
Dec 24, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kohei Yamamizu, Jun K Yamashita
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Natalia SacilottoSarah De Val
Apr 6, 2011·Future Oncology·Esther BridgesAdrian Harris
Jun 5, 2014·Nature Communications·Zhao-Qiu WuStephen J Weiss
Aug 10, 2013·Blood Cells, Molecules & Diseases·Anna BigasLeonor Gama-Norton
Mar 5, 2014·Cell and Tissue Research·Britta Engelhardt, Stefan Liebner
Mar 15, 2014·Current Opinion in Hematology·Marco Francesco Morini, Elisabetta Dejana
Jun 2, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xinguo JiangMark R Nicolls
Jul 2, 2014·Nature Reviews. Drug Discovery·Michael Kahn
Apr 27, 2013·Circulation Research·Kathrina L MarceloKaren K Hirschi
Aug 16, 2011·Current Opinion in Lipidology·Aikaterini TsaousiSarah J George
May 24, 2012·Cellular and Molecular Life Sciences : CMLS·Carol D CurtisCourtney T Griffin
Aug 13, 2015·International Journal of Molecular Sciences·Lisha QiBaocun Sun
Sep 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Shira Landskroner-EigerWilliam C Sessa
Jun 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Luca BraviMaria Grazia Lampugnani
Oct 16, 2015·World Neurosurgery·Yulius HermantoSusumu Miyamoto
Feb 3, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jason E Fish, Joshua D Wythe
Nov 14, 2015·Science·Ilaria SpadoniMaria Rescigno
Apr 7, 2016·Cancer Cell·Timothy N PhoenixRichard J Gilbertson
Sep 3, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Min ZouMengqing Xiang
Nov 23, 2011·Biochemical Society Transactions·Chern Ein Oon, Adrian L Harris

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