The woodchuck: a model for therapeutic vaccination against hepadnaviral infection

Pathologie-biologie
Michael RoggendorfMengji Lu

Abstract

Interferon-alpha and nucleoside analogues are available for the treatment of chronic hepatitis B virus (HBV) infection but do not lead to a satisfactory result. New findings about the immunological control of HBV during acute infection suggest the pivotal role of T-cell mediated immune responses. Several preclinical and clinical trials were undertaken to explore the possibility of stimulating specific immune responses in chronically infected animals and patients by vaccination. However, vaccination with commercially available HBV vaccines in patients and immunization in woodchucks with core or surface proteins of woodchuck hepatitis virus (WHV) did not result in effective control of HBV and WHV infection, suggesting that new formulations of therapeutic vaccines are needed. Some new approaches combining antiviral treatments with nucleoside analogues, DNA vaccines and protein vaccines were tested in the woodchuck model. It could be shown that therapeutic vaccinations are able to stimulate specific B- and T-cell responses and to achieve transient suppression of viral replication. These results suggest the great potential of therapeutic vaccination in combination with antivirals to reach an effective and sustained control of HBV in...Continue Reading

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Citations

Jul 4, 2013·The International Journal of Biochemistry & Cell Biology·Bo LiuYuquan Wei
Nov 10, 2013·Future Microbiology·Musa MarimaniPatrick Arbuthnot
Oct 1, 2011·Microbial Biotechnology·Sarah KutscherUlrike Protzer
Jan 18, 2011·Journal of Hepatology·Marie-Louise MichelMaryline Mancini-Bourgine
Sep 10, 2013·Seminars in Cancer Biology·Stephen LocarniniLilly Yuen

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