The Wound Healing Property of N -Methyl-(2S ,4R )-trans -4-Hydroxy-L-Proline from Sideroxylon obtusifolium is Related to its Anti-Inflammatory and Antioxidant Actions

Journal of Evidence-based Integrative Medicine
Pedro Everson Alexandre de AquinoGlauce Socorro de Barros Viana

Abstract

Wound healing involves the interaction of blood cells, proteins, proteases, growth factors, and extracellular matrix components. Inflammation is one of the first events occurring during this process. Previously, we showed that the N-Methyl-(2S,4R)-trans-4-Hydroxy-L-Proline (NMP) from Sideroxylon obtusifolium leaves (a Brazilian medicinal species) presents an anti-inflammatory action. Considering inflammation as an important event in the wound healing process, the objectives were to investigate the topical effects of the NMP gel on a mice wound-induced model. Male Swiss mice were divided into 4 groups: Sham (surgical procedure only), Control (gel-base treated), and 3% or 10% NMP gel-treated groups. Measurements of wound areas and microscopic analyses (HE [hematoxylin-eosin] and PSR [picrosirius red] stainings) were carried out, at the 7th and 12th, days after the wound induction. Furthermore, immunohistochemical assays for iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2) and biochemical measurements for TBARS (thiobarbituric acid reactive substances), GSH (glutathione), and myeloperoxidase (MPO) were also performed, at the second day after the wound induction. The work showed that NMP decreases the wound areas...Continue Reading

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Citations

Jan 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Guillermo Schmeda-HirschmannSintya Valdez

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Methods Mentioned

BETA
biopsies
MDA
ELISA

Software Mentioned

ImageJ
Image J
Graph Pad Prism
RGB Measure Plus

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