The wound is a possible source of posttraumatic immunosuppression.

Archives of Surgery
S A LazarouG Efron

Abstract

Wound fluid from 10-day-old healing wounds in rats inhibits lymphocyte immune responses. Since severe injury is frequently complicated by immunosuppression as manifested by sepsis, we hypothesized that the wound may be a source of factors that impair host immune responses. Therefore, we studied the effect of systemic wound fluid administration on the survival of rats subjected to an acute peritonitis model. Male Sprague-Dawley rats, fitted with internal jugular catheters 48 hours previously, underwent cecal ligation and puncture with a 23-gauge needle. Immediately after the operation, rats were treated intravenously every 12 hours with either wound fluid obtained from 10-day-old healing wounds and adjusted to 10 mg of protein per milliliter or rat serum. In vitro testing of the wound fluid showed it to be highly inhibitory of thymic lymphocyte mitogenesis. Rats treated with wound fluid had significantly higher mortality after peritonitis than did control rats. The data show that the wound contains factors that can impair host immune responses to sepsis. This suggests that the wound may be the source of posttraumatic host immunosuppression.

Citations

Apr 1, 1993·Annals of Surgery·L IhlbergJ Risteli
Dec 15, 2010·International Journal of Molecular Sciences·Pornanong AramwitTeerapol Srichana
Mar 27, 2007·Langenbeck's Archives of Surgery·Michael SchäfferRichard Viebahn
Jul 23, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Michael SchäfferRichard Viebahn
May 4, 2010·Burns : Journal of the International Society for Burn Injuries·Gaoxing LuoMark Fitzgerald
Dec 13, 2006·The Journal of Surgical Research·Michael SchäfferRichard Viebahn
Jan 9, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Gaoxing LuoMark Fitzgerald
Oct 6, 1998·The Journal of Surgical Research·Y Q LiW T Lawrence
Jun 5, 1998·British Journal of Plastic Surgery·S T O'Sullivan, T P O'Connor
Sep 28, 2007·Plastic and Reconstructive Surgery·Malin MalmsjöJohan Sjögren
Oct 22, 1998·The British Journal of Surgery·M L Da CostaD Bouchier-Hayes
Jul 27, 2001·Clinical and Experimental Immunology·C GouttefangeasJ Pinocy
May 1, 1995·The British Journal of Surgery·J P GriffithM J McMahon
Mar 4, 2010·Tissue Engineering. Part B, Reviews·Paula KolarGeorg N Duda
Mar 13, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jürgen PinocyGerhard Ziemer
Jun 2, 1998·The British Journal of Surgery·M Schäffer, A Barbul
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·M R SchäfferA Barbul

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.