The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells

Japanese Journal of Cancer Research : Gann
Y ShirakataK Koike

Abstract

To examine the transforming potential of the X gene product of hepatitis B virus (HBV), the X-gene-containing region (referred to as the HBx region) was introduced into mouse NIH3T3 cells. Each transformed cell line expressed X-coding mRNA at a different level. A positive correlation was found between the level of X-coding mRNA and the saturation density of the cells. The HBx-transformed cell lines exhibited X protein production and tumor formation in nude mice. The function of HBV in oncogenesis may involve the continuous expression of the X-gene-coded product in the HBV DNA-integrated cells.

References

Feb 1, 1988·Journal of Virology·D F Spandau, C H Lee
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H MizusawaK Koike
Oct 10, 1985·Nature·P TiollaisA Dejean
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K YaginumaK Koike
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R H Miller, W S Robinson
Apr 1, 1973·Virology·F L Graham, A J van der Eb
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A DejeanP Tiollais
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas

❮ Previous
Next ❯

Citations

Nov 8, 2005·Cancer Immunology, Immunotherapy : CII·Young-Hee JinSun Park
Feb 5, 1999·Journal of Hepato-biliary-pancreatic Surgery·M A Feitelson
Sep 29, 2009·Medical Molecular Morphology·Yasunobu Matsuda, Takafumi Ichida
Jul 1, 1995·Journal of Hepatology·M RennerW Koch
Apr 16, 2004·Virus Research·Jing-Chyi WangGuang-Yuh Hwang
Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·S P HussainC C Harris
Jan 8, 1999·Research in Virology·M C Kew
Apr 18, 2000·Mutation Research·S P Hussain, C C Harris
Aug 27, 2005·Mitochondrion·Kyung-Won Huh, Aleem Siddiqui
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K Q HuJ M Vierling
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·X W WangC C Harris
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·J Benn, R J Schneider
Dec 1, 1996·Nucleic Acids Research·N KuzhandaiveluE Seto
May 31, 2014·World Journal of Gastroenterology : WJG·Hoang HaiNorifumi Kawada
Aug 31, 2013·BioMed Research International·Ambreen AyubAsma Haque
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·L W ElmoreC C Harris
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P SchirmacherH P Dienes
Dec 1, 1990·Japanese Journal of Cancer Research : Gann·S Takada, K Koike
Dec 26, 2006·International Journal of Cancer. Journal International Du Cancer·Di-Peng OuLian-Yue Yang
Mar 16, 2007·Biochemical and Biophysical Research Communications·Juan GaoDaiming Fan
Jan 1, 1991·Journal of Hepatology·M SeiferW H Gerlich
Sep 29, 1999·Journal of Medical Virology·A HondaT Tokuhisa
Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·M S KangJ G Park
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B S SunM A Feitelson
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A TamoriT Kuroki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.