The X protein of Borna disease virus regulates viral polymerase activity through interaction with the P protein

The Journal of General Virology
Marion PoenischUrs Schneider

Abstract

Borna disease virus polymerase activity is negatively regulated by the viral X protein. Using a virus minireplicon system it was found that all X mutants that no longer interacted with the viral P protein failed to exhibit significant inhibitory activity. The action of X could further be neutralized by expression of a P fragment that contained the X interaction domain but lacked all domains known to mediate interaction with other viral proteins. X thus appears to regulate the activity of the Borna disease virus polymerase by targeting the polymerase cofactor P.

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Citations

Sep 12, 2006·Nature Reviews. Microbiology·Juan C de la Torre
Apr 15, 2011·Uirusu·Masayuki Horie, Keizo Tomonaga
Aug 24, 2013·Viruses·Tomoyuki Honda, Keizo Tomonaga
Oct 22, 2014·Nature Communications·Marion SzelechowskiDaniel Gonzalez-Dunia
Oct 5, 2011·Virus Research·W Ian LipkinMady Hornig
Mar 23, 2007·Journal of Virological Methods·Jonas Johansson WensmanMikael Berg
May 14, 2008·The Journal of General Virology·Marion PoenischUrs Schneider
May 8, 2009·The Journal of General Virology·Marion PoenischPeter Staeheli
May 25, 2013·The International Journal of Biochemistry & Cell Biology·Yujun LiDakang Xu
Dec 25, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cécile A FerréMarion Szelechowski
Oct 18, 2005·The Journal of General Virology·Malte SchwardtMartin Schwemmle

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