Mar 21, 2006

The X11 proteins, Abeta production and Alzheimer's disease

Trends in Neurosciences
Christopher C J MillerBoris Rogelj

Abstract

Cerebral deposition of amyloid-beta peptide (Abeta) within neuritic plaques is a hallmark pathology of Alzheimer's disease. It is now generally believed that the development of this pathology is central to the pathogenesis of Alzheimer's disease. As such, inhibiting Abeta deposition or removing Abeta deposits once they are formed represent therapeutic targets for Alzheimer's disease. Abeta is derived from a precursor, the amyloid precursor protein (APP), and APP binds to the X11 family of adaptor proteins. Studies from several laboratories have now shown that X11alpha and X11beta (the two neuronal X11s) inhibit APP processing and Abeta production. Exactly how this is achieved is not yet known but recent studies in which other X11 binding partners have been identified are beginning to reveal potential mechanisms.

  • References28
  • Citations38

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Apba1 protein, mouse
Presenilins
Familial Alzheimer Disease (FAD)
Pathogenic Aspects
Pathogenesis
APP protein, human
Carboxy-Terminal Amino Acid
MME gene
I-476 BACE isoform, human

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