The XEN of reprogramming

Cell Research
Ergin Beyret, Juan Carlos Izpisua Belmonte

Abstract

Reprogramming to pluripotency has thus far required complex procedures involving nuclear transfer, cell fusion or genetic manipulation. Two recent papers from Hongkui Deng's group now show various cell types can be reprogrammed simply by chemicals through an extraembryonic endoderm-like phase instead of the primitive streak-like mesendoderm induced by Yamanaka factors.

References

Jun 11, 2010·Nature·Shinya Yamanaka, Helen M Blau
Dec 25, 2012·Cell·Jose M PoloKonrad Hochedlinger
May 7, 2015·Nature·Jun WuJuan Carlos Izpisua Belmonte
Nov 7, 2015·Cell Stem Cell·Jun Wu, Juan Carlos Izpisua Belmonte

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Citations

Jan 6, 2018·Circulation Research·Ergin BeyretJuan Carlos Izpisua Belmonte
Oct 12, 2016·Scientific Reports·Jung Eun ParkAfonso C Silva

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