Nov 22, 2005

The Y chromosome as a target for acquired and amplified genetic material in evolution

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
V A GvozdevLev A Usakin

Abstract

The special properties of the Y chromosome stem form the fact that it is a non-recombining degenerate derivative of the X chromosome. The absence of homologous recombination between the X and the Y chromosome leads to gradual degeneration of various Y chromosome genes on an evolutionary timescale. The absence of recombination, however, also favors the accumulation of transposable elements on the Y chromosome during its evolution, as seen with both Drosophila and mammalian Y chromosomes. Alongside these processes, the acquisition and amplification of autosomal male benefit genes occur. This review will focus on recent studies that reveal the autosome-acquired genes on the Y chromosome of both Drosophila and humans. The evolution of the acquired and amplified genes on the Y chromosome is also discussed. Molecular and comparative analyses of Y-linked repeats in the Drosophila melanogaster genome demonstrate that there was a period of their degeneration followed by a period of their integration into RNAi silencing, which was beneficial for male fertility. Finally, the function of non-coding RNA produced by amplified Y chromosome genetic elements will be discussed.

  • References57
  • Citations16

Citations

Mentioned in this Paper

Fertility
Y Chromosome
Abnormal Degeneration
Gene Amplification
Genome
RNA, Untranslated
Infertility Study
Nerve Degeneration
Recombination, Genetic
Drosophila

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