Abstract
Barrett's esophagus (BE) is a metaplastic condition of the distal esophagus, resulting from longstanding gastroesophageal reflux disease (GERD). BE predisposes for the highly malignant esophageal adenocarcinoma (EAC). Both BE and EAC have the highest frequencies in white males. Only a subset of patients with GERD develop BE, while <0.5% of BE will progress to EAC. Therefore, it is most likely that the development of BE and EAC is associated with underlying genetic factors. We hypothesized that in white males, Y-chromosomal haplogroups are associated with BE and EAC. To investigate this we conducted a multicenter study studying the frequencies of the Y-chromosomal haplogroups in GERD, BE, and EAC patients. We used genomic analysis by polymerase chain reaction and restriction fragment length polymorphism to determine the frequency of six Y-chromosomal haplogroups (DE, F(xJ,xK), K(xP), J, P(xR1a), and R1a) between GERD, BE, and EAC in a cohort of 1,365 white males, including 612 GERD, 753 BE patients, while 178 of the BE patients also had BE-associated EAC. Univariate logistic regression analysis was used to compare the outcomes. In this study, we found the R1a (6% vs. 9%, P = 0.04) and K (3% vs. 6%, P = 0.035) to be significantly...Continue Reading
References
Aug 1, 1989·Diabetes·N J Cox, G I Bell
Oct 15, 1989·Cancer Genetics and Cytogenetics·H S GarewalJ M Trent
Oct 23, 1997·Genome Research·P A UnderhillP J Oefner
Feb 10, 2000·The American Journal of Pathology·A K WalchM Werner
Nov 4, 2000·Nature Genetics·P A UnderhillP J Oefner
Jun 21, 2001·Annals of Human Genetics·P A UnderhillL L Cavalli-Sforza
Mar 8, 2002·Hypertension·Fadi J CharcharAnna F Dominiczak
Aug 5, 2003·Nature Reviews. Genetics·Mark A Jobling, Chris Tyler-Smith
Oct 7, 2003·Nature Genetics·Sjoerd ReppingSteve Rozen
Jan 16, 2004·Gastroenterology·Douglas K RexDebra J Helper
Dec 4, 2004·Alimentary Pharmacology & Therapeutics·M Hongo
Feb 25, 2005·Gastrointestinal Endoscopy·Brenda WesthoffPrateek Sharma
Aug 4, 2005·American Journal of Epidemiology·Alexander C FordPaul Moayyedi
Nov 22, 2005·Journal of Surgical Oncology·Manuel PeraLuis Grande
Dec 29, 2005·American Journal of Human Genetics·Katherine L NathansonElizabeth A Rapley
Feb 28, 2006·Nature Genetics·Sjoerd ReppingSteve Rozen
Jan 25, 2007·PloS One·Wook KimYoon-Sun Bae
Apr 22, 2008·Gut·R M ZagariF Bazzoli
Oct 15, 2008·Cancer Causes & Control : CCC·Ai KuboDouglas A Corley
Oct 16, 2008·The American Journal of Gastroenterology·Douglas A CorleyGladys Block
Dec 30, 2008·Gastroenterology·Ai KuboDouglas A Corley
Jan 24, 2009·Gastroenterology·Lesley A AndersonLiam J Murray
Mar 26, 2009·The American Journal of Gastroenterology·Zoe R EdelsteinThomas L Vaughan
Sep 29, 2011·The American Journal of Gastroenterology·Jukka RonkainenPertti Aro
Jan 17, 2012·Gastroenterology·Michael B CookDouglas A Corley
Dec 12, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jennifer R KramerHashem B El-Serag
Jun 25, 2015·Gut·Margriet R TimmerKausilia K Krishnadath
Jul 26, 2015·Gastroenterology·Brian J ReidXiaohong Li
Aug 20, 2016·Nature Communications·Pierre MartinezKausilia K Krishnadath
Oct 27, 2017·PloS One·Xiangqing SunAmitabh Chak
May 28, 2019·Nature Reviews. Disease Primers·Yonne PetersPeter D Siersema