Jul 1, 1987

The yeast homologue of U3 snRNA

The EMBO Journal
J M HughesG Cesareni

Abstract

snR17, one of the most abundant capped small nuclear RNAs of Saccharomyces cerevisiae, is equivalent to U3 snRNA of other eukaryotes. It is 328 nucleotides in length, 1.5 times as long as other U3 RNAs, but shares significant homology both in nucleotide sequence and in predicted secondary structure. Human scleroderma antiserum specific to nucleolar U3 RNP can enrich snR17 from sonicated yeast nuclear extracts. Unlike other yeast snRNAs which are encoded by single copy genes, snR17 is encoded by two genetically unlinked genes: SNR17A and SNR17B. The RNA snR17A is more abundant than snR17B. Deleting one or other of the genes has no obvious phenotypic effect, except that the steady-state level of snR17B is increased in snr17a- strains. Haploid strains with both genes deleted are inviable, therefore yeast U3 is essential.

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Mentioned in this Paper

Scleroderma
Scleroderma <fungus>
Small Nuclear RNA
RNA Conformation
Alkalescens-Dispar Group
Saccharomyces cerevisiae allergenic extract
Immune Sera
Genes, Fungal
Nucleolar
Homologous Sequences, Nucleic Acid

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