The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis

Cells
Giulia CazzanelliAna Preto

Abstract

The exploitation of the yeastSaccharomyces cerevisiaeas a biological model for the investigation of complex molecular processes conserved in multicellular organisms, such as humans, has allowed fundamental biological discoveries. When comparing yeast and human proteins, it is clear that both amino acid sequences and protein functions are often very well conserved. One example of the high degree of conservation between human and yeast proteins is highlighted by the members of the RAS family. Indeed, the study of the signaling pathways regulated by RAS in yeast cells led to the discovery of properties that were often found interchangeable with RAS proto-oncogenes in human pathways, and vice versa. In this work, we performed an updated critical literature review on human and yeast RAS pathways, specifically highlighting the similarities and differences between them. Moreover, we emphasized the contribution of studying yeast RAS pathways for the understanding of human RAS and how this model organism can contribute to unveil the roles of RAS oncoproteins in the regulation of mechanisms important in the tumorigenic process, like autophagy.

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Citations

Jun 21, 2019·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Julia María Coronas-SernaVíctor J Cid
Dec 14, 2018·Frontiers in Pharmacology·Antonella StoppacciaroPatrizia Filetici
Nov 1, 2020·International Journal of Molecular Sciences·Sudip Dhakal, Ian Macreadie
Jan 18, 2019·Computational Biology and Chemistry·Vladimir Vélez-SegarraElsie I Parés-Matos

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Methods Mentioned

BETA
acylation
GTPase
ubiquitination

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