PMID: 9555915Apr 29, 1998Paper

The yhhP gene encoding a small ubiquitous protein is fundamental for normal cell growth of Escherichia coli

Journal of Bacteriology
T YamashinoT Mizuno

Abstract

H-NS is a major constituent of the Escherichia coli nucleoid, whereas sigmaS is a stress-induced sigma factor. An hns null mutation affects the cellular content of sigmaS in such a way that a remarkable accumulation of sigmaS is observed in the logarithmic growth phase, which results in enhanced expression of a number of sigmaS-dependent genes, including the katE gene. We isolated an extragenic mutation that affects the expression of the katE-lacZ fusion gene in the deltahns background. The relevant gene was identified as yhhP, which encodes a small polypeptide of 81 amino acids. Lesion of this gene seemed to affect the stability of sigmaS. A deletion analysis of yhhP revealed that this small protein plays a fundamental role in the general physiology of E. coli. The yhhP-deficient cell is not capable of growing in standard laboratory rich medium (i.e., Luria broth), resulting in the formation of filamentous cells. Homologs of this intriguing protein occur in a wide variety of bacterial species, including archaeal species.

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Citations

Mar 22, 2014·The Journal of Biological Chemistry·Yvonne StockdreherChristiane Dahl
Mar 21, 2006·Nature Chemical Biology·Charles T Lauhon
Jul 31, 2013·MicrobiologyOpen·Stanislav G KozminRoel M Schaaper
Mar 13, 2012·Journal of Bacteriology·A BattestiS Gottesman
Sep 19, 2006·Journal of Bacteriology·YanNing Zhou, Susan Gottesman
Feb 3, 2021·Journal of Bacteriology·Tugba Yildiz, Silke Leimkühler
May 1, 2014·EcoSal Plus·Glenn R Björk, Tord G Hagervall
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·M K Berlyn
Sep 9, 2019·ACS Biomaterials Science & Engineering·Thomas R AuninsAnushree Chatterjee

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