The yield of bone marrow biopsy and culture compared with blood culture in the evaluation of HIV-infected patients for mycobacterial and fungal infections

The American Journal of Medicine
J M KilbyK B Waites

Abstract

To compare the clinical utility of bone marrow biopsy and culture specimens with blood cultures for mycobacterial and fungal infections among human immunodeficiency virus (HIV)-infected patients. All bone marrow biopsies obtained from HIV-infected patients at the University of Alabama at Birmingham (UAB) Medical Center during 1993 to 1995 were blindly reviewed in a standardized format. Bone marrow culture results and blood culture results obtained within 6 weeks of each bone marrow study were compiled. Medical records were reviewed to determine indications for performing bone marrow biopsies, empiric or prophylactic antimicrobial therapies preceding the biopsy, and CD4 counts. Eighty-two bone marrow studies were obtained from 76 patients. Most were performed during the evaluation of fever, cytopenia, or weight loss. Of 55 bone marrow mycobacterial cultures, 13 yielded Mycobacterium avium complex (MAC) and 2 yielded M tuberculosis (MTB). Of 51 bone marrow fungal cultures performed, 2 yielded Cryptococcus neoformans and 1 Histoplasma capsulatum. All patients with a bone marrow culture positive for MAC had a CD4 count of 20 cells/mm3 or less. The mean CD4 count in this group (+/-95% confidence interval) (8+/-3 cells/mm3) was lower...Continue Reading

References

Mar 11, 1992·The Journal of Infectious Diseases·J A HavlikS E Thompson
May 9, 1991·The New England Journal of Medicine·C R Horsburgh
Aug 1, 1994·The Journal of Infectious Diseases·C A KemperS C Deresinski
Mar 23, 1994·JAMA : the Journal of the American Medical Association·R M Selik, S Y Chu
Sep 16, 1993·The New England Journal of Medicine·S D NightingaleD L Kaufman
May 1, 1994·The American Journal of Medicine·D W Haas, R M Des Prez
Jul 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A Benson, J J Ellner
Sep 1, 1993·The Journal of Infectious Diseases·J A BarretoP A Galvão
Apr 1, 1996·The Journal of Infectious Diseases·F J TorrianiD V Havlir
Apr 1, 1996·Annals of Internal Medicine·R D Moore, R E Chaisson
Jul 1, 1996·Clinical Nuclear Medicine·H M Abdel-DayemJ Gillooley

❮ Previous
Next ❯

Citations

Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John A Crump, L Barth Reller
Oct 31, 2013·Epidemiology and Infection·S-H LinP-R Hsueh
Jul 24, 2002·Archives of Pharmacal Research·Rafik SamuelByungse Suh
Nov 14, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L GazzolaA Gori
Jan 15, 2008·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K GopinathS Singh
Dec 7, 2007·Infectious Disease Clinics of North America·Arnaud HotOlivier Lortholary
Mar 17, 2015·The Lancet. Respiratory Medicine·Elisa López-VarelaBeate Kampmann
Feb 15, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ali MertSedat Altin
Aug 11, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E PaciosE Bouza
Sep 28, 2010·Journal of Infection and Public Health·Arindam PandeAjanta Samanta
Jul 1, 2008·Expert Review of Anti-infective Therapy·Marcelo Corti, Domingo Palmero
May 20, 2009·International Journal of STD & AIDS·C BabuM Kingston
Apr 13, 1999·Transplantation·A CastelloE Arbustini
Nov 23, 2017·Journal of Investigative Medicine High Impact Case Reports·Folusakin AyoadeAndrew Stevenson Joel Chandranesan
Jul 31, 2004·Journal of Pediatric Hematology/oncology·Omar A Abdul-RahmanGail C Megason
Apr 6, 2004·Journal of Clinical Laboratory Analysis·Roger S RileyJonathan M Ben-Ezra
Jan 16, 2007·Medicine·Jann-Yuan WangKwen-Tay Luh
Nov 25, 2003·Hematology·Paul A VolberdingAlexandra M Levine
Dec 4, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Edgardo S SantosGerald E Byrne
Sep 10, 2013·Journal of Laboratory Physicians·Rashmi ShresthaShyamal Kumar Bhattacharya
Jan 16, 2015·Journal of Clinical Pathology·Andrés E QuesadaLei Chen
Oct 30, 2020·Respiratory Medicine Case Reports·Mary Rithu VarkeyNicole C Lapinel
Aug 17, 2021·Skeletal Radiology·Anderanik Tomasian, Jack W Jennings

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.