The zebrafish: a model to study the endogenous mechanisms of pain

ILAR Journal
Veronica Gonzalez-Nunez, R E Rodriguez

Abstract

The difficulty of designing new analgesic drugs is evident in the biochemical maze that results when an opioid agonist binds to opioid receptors, triggering a complex cascade of intracellular mechanisms. In an effort to enhance understanding of the biochemical and pharmacological mechanisms that are responsible for the action of opioid drugs, we describe the characterization of the zebrafish opioid system, a novel experimental approach to unravel the molecular mechanisms that underlie opioid activity. We have cloned the zebrafish opioid receptors and peptides, established their expression pattern during development and in the adult organism, and determined their pharmacological profiles and biochemical properties. Furthermore, developmental studies in the zebrafish yield valuable information about the developmental roles of the opioid receptors. Building on these findings, we show that the zebrafish opioid receptors and peptides present molecular, pharmacological, and biochemical profiles that are fundamentally similar to those of their mammalian counterparts and from which results can therefore be extrapolated to higher vertebrates. Thus the zebrafish represents a straightforward model to study opioid activity, and can be very...Continue Reading

Citations

Apr 18, 2013·Zebrafish·Allan V KalueffUNKNOWN Zebrafish Neuroscience Research Consortium
Jan 26, 2013·Molecular Medicine·Veronica Gonzalez-NunezRaquel E Rodríguez
Jul 21, 2011·Organic & Biomolecular Chemistry·Gemma ArsequellGregorio Valencia
Dec 22, 2012·Journal of Molecular Endocrinology·Roger López-BellidoRaquel E Rodríguez
Feb 6, 2016·Journal of Wildlife Diseases·Constance Silbernagel, Pamela Yochem
Mar 27, 2013·Neuroscience·Roger López-BellidoRaquel Emilia Rodríguez
Dec 3, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam StewartAllan V Kalueff
Apr 6, 2013·Journal of Cellular Physiology·Valentina MalafogliaGianfranco Bellipanni
Feb 18, 2014·British Journal of Pharmacology·N Percie du Sert, A S C Rice
Aug 10, 2013·Journal of Cellular Physiology·Valentina MalafogliaGianfranco Bellipanni
Jan 15, 2014·Trends in Pharmacological Sciences·Allan V KalueffRobert Gerlai
Jan 19, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Evan J KyzarAllan V Kalueff
Sep 21, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Masoume KaramiSoghrat Faghihzadeh
Apr 21, 2017·The Journal of Experimental Biology·Javier Lopez-LunaLynne U Sneddon
Aug 29, 2018·Zebrafish·Francisco Ernani Alves MagalhãesAdriana Rolim Campos
Sep 4, 2014·PloS One·Bruno C R RamosAna Maria L Castrucci
Dec 8, 2015·Journal of Biomolecular Screening·Daniëlle CopmansPeter A M de Witte
Jul 5, 2016·Journal of Neuroscience Research·Nicole E BurmaTuan Trang
Jul 14, 2017·Zebrafish·Francisco Ernani Alves MagalhãesAdriana Rolim Campos
Jul 24, 2020·The Journal of Experimental Biology·Jack S ThomsonLynne U Sneddon
Nov 15, 2020·Journal of Neuroscience Methods·Cynthia AbboudMarc Landry
Apr 1, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Konstantin A DeminAllan V Kalueff
Mar 17, 2021·Toxicology and Applied Pharmacology·Krishna Tulasi KirlaThomas Kraemer
Apr 27, 2021·Frontiers in Neuroscience·Nils OhnesorgeLars Lewejohann
May 16, 2021·Pharmacology, Biochemistry, and Behavior·Murilo S de AbreuAllan V Kalueff
Jun 21, 2019·Neuroscience Letters·Fabiano V CostaDenis B Rosemberg
Aug 22, 2021·Journal of Ethnopharmacology·Mahima SharmaDebapriya Garabadu

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