The zebrafish as a model organism for the study of apoptosis

Apoptosis : an International Journal on Programmed Cell Death
P M Eimon, Avi Ashkenazi


Apoptosis plays important roles in embryogenesis, tissue homeostasis, and immune system regulation. The zebrafish (Danio rerio) is a powerful vertebrate model organism that has been extensively used to study apoptotic cell death during normal development and under conditions of cellular stress. In the past 5 years, a detailed picture has begun to emerge of the molecular underpinnings of the cell-intrinsic and the cell-extrinsic apoptosis signaling pathways in zebrafish. We begin this review with an introduction to the techniques and experimental approaches that are used to study apoptosis in zebrafish. We follow with a general overview of developmental apoptosis during zebrafish embryogenesis. Finally, we present a comprehensive review of the intrinsic and extrinsic apoptosis pathways in zebrafish, focusing on the high degree of conservation with humans and other mammals. Recent publications that draw upon the unique advantages of the zebrafish system to study novel aspects of apoptosis regulation and function are highlighted throughout.


Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jan 1, 1995·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·W C Michel, L M Lubomudrov
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·K NakayamaD Y Loh
Dec 1, 1996·Development·M Furutani-SeikiC Nüsslein-Volhard
Jan 1, 1997·Developmental Genetics·J M FadoolJ E Dowling
Mar 5, 1998·Mechanisms of Development·C Hensey, J Gautier
Jan 1, 1997·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M Rodriguez, W Driever
May 15, 1998·Neuron·B Pettmann, C E Henderson
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Feb 8, 2000·The Journal of Comparative Neurology·H LangD M Fekete
Apr 20, 2000·Hearing Research·J A Williams, N Holder
Aug 5, 2000·Cell Death and Differentiation·N Inohara, G Nuñez
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker
Oct 26, 2000·Nature·P MeierG Evan
Dec 19, 2000·Biochemical and Biophysical Research Communications·M C ChenJ L Wu
Jun 12, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·J Bobe, F W Goetz
Aug 3, 2001·Apoptosis : an International Journal on Programmed Cell Death·J BaeA J Hsueh
Sep 7, 2001·Genes & Development·R T Abraham
Nov 1, 2001·Nature Neuroscience·T W Gould, R W Oppenheim
Nov 10, 2001·Cell and Tissue Research·O BiehlmaierK Kohler
Jan 11, 2002·Developmental Biology·L K Cole, L S Ross
May 23, 2002·Developmental Cell·Hyunsook Lee, David Kimelman
Jul 6, 2002·Science·Erno WienholdsRonald H A Plasterk
Aug 31, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·S SpanosK Hardy
Sep 5, 2002·Nature Reviews. Cancer·Suzanne Cory, Jerry M Adams
Sep 17, 2002·Cell Death and Differentiation·G van LooP Vandenabeele
Dec 5, 2002·The Journal of Biological Chemistry·Junya MasumotoNaohiro Inohara
Mar 15, 2003·European Journal of Ophthalmology·Y H Mohamed, T Amemiya

❮ Previous
Next ❯


Feb 4, 2010·Apoptosis : an International Journal on Programmed Cell Death·Frank van BreukelenJason E Podrabsky
Jan 14, 2011·Fish Physiology and Biochemistry·Ksenia J GrohMarc J-F Suter
Jan 22, 2011·Cell Death and Differentiation·E Rodríguez-Aznar, M A Nieto
Aug 15, 2013·Nature Communications·Julien PrudentGermain Gillet
Sep 17, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Anastasia EmmanouilidouThomais Papamarcaki
Apr 17, 2012·PloS One·Woei Chang LiewLaszlo Orban
Nov 30, 2013·Neurotoxicology and Teratology·Luís M FélixAna M Coimbra
Aug 26, 2014·Annual Review of Cell and Developmental Biology·Avi Ashkenazi, Guy Salvesen
May 15, 2013·Fish Physiology and Biochemistry·Heng-Ju LinJyh-Yih Chen
Aug 24, 2013·Expert Opinion on Drug Discovery·Patricia McGrath, Wen Lin Seng
Feb 19, 2016·Journal of Applied Toxicology : JAT·Talita Carneiro Brandão PereiraMaurício Reis Bogo
Jan 19, 2016·Journal of Hazardous Materials·Yang YangChengju Wang
May 20, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ming-Chuan LiYong-Bing Xiang
May 9, 2012·Biochemical and Biophysical Research Communications·Yigen LiCheng Huang
Apr 30, 2011·Developmental and Comparative Immunology·Gregory D Wiens, Gavin W Glenney
Dec 23, 2014·Developmental Neurobiology·Ming-Yuan TsaiSheng-Ping L Hwang
Jul 22, 2010·Cell Biochemistry and Function·Sunhee LeeSoojin Lee
Oct 15, 2013·Journal of Morphology·Ekaterina Alexandrovna A Kondakova, Vladimir Ivanovich I Efremov
Dec 24, 2013·American Journal of Human Genetics·Francine P FavaroMaria Rita Passos-Bueno
Apr 12, 2016·Scientific Reports·Patricia Pais-RoldánXin Yu
Jun 30, 2016·Developmental and Comparative Immunology·Zihao YuanZhanjiang Liu
Feb 28, 2018·The Journal of Biological Chemistry·Suresh BanjaraMarc Kvansakul
Apr 16, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Seyed Mohammad MousaviHamed Kord Varkaneh

❮ Previous
Next ❯

Related Concepts

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Apoptosis : an International Journal on Programmed Cell Death
Gerhard Krumschnabel, Jason E Podrabsky
Disease Models & Mechanisms
Marina C Mione, Nikolaus S Trede
© 2021 Meta ULC. All rights reserved