The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development

Developmental Biology
Randolph P MatthewsMichael Pack

Abstract

Targeted disruption of the onecut transcription factor, hnf-6, alters mammalian biliary system development. We have identified a related zebrafish cDNA expressed in the developing liver that is a functional ortholog of mammalian hnf-6. Antisense-mediated knockdown of zebrafish hnf-6 perturbs development of the intrahepatic biliary system. Knockdown of zebrafish hnf-6 alters expression of vhnf1 and the zebrafish orthologs of other mammalian genes regulated by hnf-6. Coinjection of mRNA encoding zebrafish vhnf1 rescues the biliary phenotype of hnf-6 morphants. These experiments strongly suggest that hnf-6 and vhnf1 function within an evolutionarily conserved pathway that regulates biliary development. Forced expression of either hnf-6 or vhnf1 also produces biliary phenotypes. Altered bile duct development in both loss- and gain-of-function experiments suggests that zebrafish biliary cells are sensitive to the dosage of hnf-6-mediated gene transcription.

References

Aug 1, 1994·Seminars in Liver Disease·I D D'AgataL M Guay-Woodford
Jan 4, 1998·Microscopy Research and Technique·N Shiojiri
Jan 19, 1999·Methods in Cell Biology·T M Hyatt, S C Ekker
May 4, 2001·Mechanisms of Development·S KorzhV Korzh
Feb 19, 2002·Mechanisms of Development·Sung-Kook HongTae-Lin Huh
May 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ai-Xuan L HoltermanRobert H Costa
Oct 3, 2002·Seminars in Liver Disease·James M Crawford
Dec 20, 2002·Mechanisms of Development·Frédéric P Lemaigre
Mar 6, 2003·Developmental Biology·Kenneth N Wallace, Michael Pack
May 15, 2003·Journal of Medical Genetics·C A JohnsonC Sergi
Oct 22, 2003·Journal of Hepatology·Frédéric ClotmanFrédéric P Lemaigre

❮ Previous
Next ❯

Citations

Mar 2, 2013·Zebrafish·Shuang CuiRandolph P Matthews
Jan 23, 2013·Gastroenterology·Shuang CuiRandolph P Matthews
Nov 5, 2013·Drug Discovery Today. Disease Models·Jessica P Otis, Steven A Farber
May 30, 2015·Mechanisms of Development·Mehwish KhaliqDonghun Shin
Dec 27, 2005·Clinics in Liver Disease·Valérie A McLin, Aaron M Zorn
Sep 1, 2015·Gastroenterology·Wolfram Goessling, Kirsten C Sadler
Aug 21, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jaime Chu, Kirsten C Sadler
Dec 21, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Randolph P MatthewsMichael Pack
Oct 16, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alphonse E SiricaNicholas F Larusso
Aug 11, 2011·The Journal of Comparative Neurology·Fuguo WuXiuqian Mu
Jun 27, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Yiwei Zong, Ben Z Stanger
Sep 8, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Charles VanderpoolStacey S Huppert
Feb 15, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Randolph P MatthewsMichael Pack
Aug 27, 2010·Journal of Fish Biology·W-T Huang, C-F Weng
Jan 29, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kristin LorentMichael Pack
Oct 25, 2011·Developmental Biology·Isla D CheungDidier Y R Stainier
Apr 12, 2015·Current Opinion in Genetics & Development·Andrew G Cox, Wolfram Goessling
Apr 3, 2012·Developmental Biology·Steven F EauClaireRandolph P Matthews
Jan 10, 2012·Developmental Biology·Madeline SchaubTakuya F Sakaguchi
Apr 1, 2014·Developmental Biology·Maria Rosa PezzottiMargherita Branno
Jul 22, 2009·Developmental Cell·Jason R SpenceJames M Wells
Jan 11, 2011·Developmental Biology·Shuang CuiRandolph P Matthews
Apr 25, 2006·Developmental Biology·Wei ChengJinrong Peng
Sep 14, 2012·PLoS Biology·Christoph SeilerMichael Pack
Oct 22, 2016·Journal of Pediatric Gastroenterology and Nutrition·Vivian TangRandolph P Matthews
Dec 27, 2018·Current Opinion in Gastroenterology·Muriel Girard, Ganna Panasyuk
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roong Zhao, Stephen A Duncan
Dec 6, 2017·Journal of Anatomy·Nobuyoshi ShiojiriHayato Kawakami
Aug 28, 2020·Frontiers in Physiology·Jun MinShankar Subramaniam
Nov 4, 2017·Current Pathobiology Reports·Duc-Hung PhamChunyue Yin
May 21, 2019·Cellular and Molecular Gastroenterology and Hepatology·Paul J WrightonWolfram Goessling
Jul 19, 2008·Development·Ludmilla LokmaneSilvia Cereghini
Jun 23, 2009·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ting Tao, Jinrong Peng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.