The zebrafish prospero homolog prox1 is required for mechanosensory hair cell differentiation and functionality in the lateral line.

BMC Developmental Biology
Anna PistocchiFranco Cotelli

Abstract

The lateral line system in zebrafish is composed of a series of organs called neuromasts, which are distributed over the body surface. Neuromasts contain clusters of hair cells, surrounded by accessory cells. In this report we describe zebrafish prox1 mRNA expression in the migrating primordium and in the neuromasts of the posterior lateral line. Furthermore, using an antibody against Prox1 we characterize expression of the protein in different cell types within neuromasts, and we show distribution among the supporting cells and hair cells. Functional analysis using antisense morpholinos indicates that prox1 activity is crucial for the hair cells to differentiate properly and acquire functionality, while having no role in development of other cell types in neuromasts.

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Citations

Jan 5, 2012·PloS One·Xiaowen ChenZhan Yin
Mar 7, 2014·Scientific Reports·Siau-Lin LohVladimir Korzh
May 8, 2019·International Journal of Molecular Sciences·Magdalena RudzińskaBarbara Czarnocka
Jan 29, 2022·Npj Regenerative Medicine·Susanna E RileyCarsten Gram Hansen

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