PMID: 1825351Mar 1, 1991

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A

Molecular and Cellular Biology
J Michael RuppertK W Kinzler

Abstract

The GLI gene was previously isolated by virtue of its amplification in human glioblastomas. We have now found that GLI expression can result in the in vitro transformation of both primary and secondary rodent cells. When coexpressed with adenovirus E1A, the GLI protein functions analogously to RAS, resulting in the formation of dense foci of cells which are tumorigenic in nude mice.

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Related Concepts

Neoplastic Cell Transformation
DNA Helix Destabilizing Proteins
Genes, Reiterated
Mixed Gliomas
Nucleolar Proteins
Oncogene Proteins, Viral
Transcription Factor
Zinc Fingers
Adenovirus E29 Protein

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