The zinc-responsive regulator Zur controls expression of the coelibactin gene cluster in Streptomyces coelicolor.

Journal of Bacteriology
Dimitris KallifidasM S Paget

Abstract

Streptomyces coelicolor mutants lacking the zinc-responsive Zur repressor are conditionally defective in sporulation, presumably due to the overexpression of one or more Zur target genes. Gene disruption analyses revealed that deregulation of previously known Zur targets was not responsible for the sporulation phenotype. We used microarrays to identify further Zur targets and discovered that Zur controls a cluster of genes predicted to direct synthesis of an uncharacterized siderophore-related non-ribosomally encoded peptide designated coelibactin. Disruption of a key coelibactin biosynthetic gene suppressed the Zur sporulation phenotype, suggesting that deregulation of coelibactin synthesis inhibits sporulation.

Associated Datasets

References

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Citations

Jul 17, 2012·Nature Reviews. Microbiology·M Indriati Hood, Eric P Skaar
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jung-Ho ShinJung-Hye Roe
Mar 9, 2013·Microbiology and Molecular Biology Reviews : MMBR·Gang LiuHuarong Tan
Sep 4, 2012·International Journal of Molecular Sciences·Bin ZhaoDavid C Lamb
Jun 25, 2010·Molecular Microbiology·Benjamin J ThompsonMatthew I Hutchings
Aug 31, 2012·Molecular Microbiology·Matthew F TraxlerRoberto Kolter
Oct 9, 2014·Journal of Applied Microbiology·Suzy C Moody, E Joel Loveridge
Jun 10, 2017·Nature Communications·Seung-Hwan ChoiJung-Hye Roe
Mar 13, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Timothy C Johnstone, Elizabeth M Nolan
Sep 13, 2017·Molecular Microbiology·Maria Chiara MastropasquaAndrea Battistoni
Apr 8, 2010·Natural Product Reports·Jonathan A R Worrall, Erik Vijgenboom
Sep 23, 2014·Environmental Microbiology·Violeta C Sein-EchaluceMaría F Fillat
May 20, 2020·Natural Product Reports·Marika HofmannDirk Tischler
May 26, 2011·Natural Product Reports·Gilles P van Wezel, Kenneth J McDowall
Apr 26, 2016·Metallomics : Integrated Biometal Science·Fabricio M LocatelliDana Ulanova
Oct 27, 2015·Metallomics : Integrated Biometal Science·Li MaAnthony W Maresso
Aug 2, 2018·Biochemical Society Transactions·Alevtina MikhaylinaClaudia A Blindauer
Nov 26, 2010·Chemical Reviews·Joanne M Willey, Alisa A Gaskell
Jul 25, 2021·Metallomics : Integrated Biometal Science·Katherine A EdmondsDavid P Giedroc

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