Mar 30, 2007

The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling

Archives of Biochemistry and Biophysics
Artur KrezelWolfgang Maret

Abstract

Free zinc ions are potent effectors of proteins. Their tightly controlled fluctuations ("zinc signals") in the picomolar range of concentrations modulate cellular signaling pathways. Sulfur (cysteine) donors generate redox-active coordination environments in proteins for the redox-inert zinc ion and make it possible for redox signals to induce zinc signals. Amplitudes of zinc signals are determined by the cellular zinc buffering capacity, which itself is redox-sensitive. In part by interfering with zinc and redox buffering, reactive species, drugs, toxins, and metal ions can elicit zinc signals that initiate physiological and pathobiochemical changes or lead to cellular injury when free zinc ions are sustained at higher concentrations. These interactions establish redox-inert zinc as an important factor in redox signaling. At the center of zinc/redox signaling are the zinc/thiolate clusters of metallothionein. They can transduce zinc and redox signals and thereby attenuate or amplify these signals.

  • References104
  • Citations99

References

  • References104
  • Citations99

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Establishment and Maintenance of Localization
Zinc Fingers
Buffers
Biochemical Pathway
Fluctuation
Cations, Divalent
Ethanol
Thionine
Zinc Ion Binding

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Journal of the American Chemical Society
Artur Krezel, Wolfgang Maret
Proceedings of the National Academy of Sciences of the United States of America
Stefano L SensiJohn H Weiss
Nature Reviews. Neuroscience
Christopher FredericksonAshley I Bush
Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Artur Krezel, Wolfgang Maret
© 2020 Meta ULC. All rights reserved