The zoonotic potential of Clostridium difficile from small companion animals and their owners

PloS One
Denise RaboldAntina Lübke-Becker

Abstract

Clostridium difficile infections (CDI) in humans range from asymptomatic carriage to life-threatening intestinal disease. Findings on C. difficile in various animal species and an overlap in ribotypes (RTs) suggest potential zoonotic transmission. However, the impact of animals for human CDI remains unclear. In a large-scale survey we collected 1,447 fecal samples to determine the occurrence of C. difficile in small companion animals (dogs and cats) and their owners and to assess potential epidemiological links within the community. The Germany-wide survey was conducted from July 2012-August 2013. PCR ribotyping, Multilocus VNTR Analysis (MLVA) and PCR detection of toxin genes were used to characterize isolated C. difficile strains. A database was defined and logistic regression used to identify putative factors associated with fecal shedding of C. difficile. In total, 1,418 samples met the inclusion criteria. The isolation rates for small companion animals and their owners within the community were similarly low with 3.0% (25/840) and 2.9% (17/578), respectively. PCR ribotyping revealed eight and twelve different RTs in animals and humans, respectively, whereas three RTs were isolated in both, humans and animals. RT 014/0, a w...Continue Reading

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Jun 13, 2019·Zoonoses and Public Health·J Scott WeeseFrederic Lohr
Jan 7, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J Scott Weese
Dec 4, 2019·Journal of Animal Physiology and Animal Nutrition·Giada MorelliRebecca Ricci
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Oct 17, 2020·Frontiers in Veterinary Science·Belen G HernandezShankumar Mooyottu
Aug 13, 2021·Expert Review of Anti-infective Therapy·Chin-Shiang TsaiWen-Chien Ko

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

STATA®
STATA

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