Theanine enhanced both the toxicity of strychnine and anticonvulsion of pentobarbital sodium

Drug and Chemical Toxicology
Xi-Chong YuWei Yang

Abstract

Theanine, an additive, holds several effects on the central nervous system without toxicity and affects CNS drugs. Theanine bilaterally alters β wave of the EEG with or without caffeine and pentobarbital-induced locomotor activity. Theanine also enhances hypnosis of pentobarbital sodium (PB) and antidepression of midazolam, suggesting there are complicated interactions between theanine and CNS drugs. On the other side, theanine induces glycine release. Glycine potentiates the strychnine toxicity via NMDA receptor activation. Moreover, PB facilitates GABAA receptor activation by GABA, and it is commonly prescribed for strychnine poison. However, what the role that theanine plays in the anticonvulsion of PB against strychnine poison is still unknown. Theanine, pentobarbital sodium or strychnine was injected intraperitoneally. EEG was monitored by BIOPAC 16 EEG amplifiers. LD50 of strychnine and hypnotic ED50 of pentobarbital sodium with or without theanine for mice were tested according to Bliss' case. (1) Theanine enhanced the strychnine toxicity. Both theanine and strychnine 1.0 mg/kg increased the power of the β wave. Theanine aggravated that of strychnine 1.0 mg/kg. Theanine attenuated the LD50 of strychnine. (2) Theanine enh...Continue Reading

References

May 1, 1978·British Journal of Pharmacology·N G Bowery, A Dray
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 29, 2000·Bioscience, Biotechnology, and Biochemistry·T KakudaO Okai
Feb 25, 2003·Bioscience, Biotechnology, and Biochemistry·Takami KakudaHitoshi Niino
May 26, 2004·Neuroscience Letters·Nobuaki EgashiraMichihiro Fujiwara
Oct 19, 2004·Experimental Brain Research·A BarthD W Newell
Dec 29, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M SchmidtD Schrenk
Jun 9, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J F BorzellecaW Hall
Aug 21, 2007·Phytotherapy Research : PTR·Nobuaki EgashiraMichihiro Fujiwara
Oct 12, 2007·Journal of Pharmacological Sciences·Nobuaki EgashiraMichihiro Fujiwara
Apr 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Patricia L Brooks, John H Peever
Aug 7, 2008·Nutritional Neuroscience·Gail N OwenJane A Rycroft
Dec 21, 2010·Child: Care, Health and Development·D R CrossH Huisman
Mar 23, 2011·Phytotherapy Research : PTR·Cui YinXuemei Zhuang
Apr 12, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Takami Kakuda
Aug 24, 2011·Psychopharmacology·Chisato WakabayashiHiroshi Kunugi

❮ Previous
Next ❯

Citations

Aug 15, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Filipe Lopes SakamotoHeitor Oliveira Santos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.