PMID: 2508037Aug 1, 1989Paper

Theilerial parasites isolated from carrier cattle after immunization with Theileria parva by the infection and treatment method

Parasitology
A C MaritimD A Stagg

Abstract

Groups of cattle were immunized with 10(-2) dilutions of sporozoite stabilates of Theileria parva lawrencei derived from African buffaloes either alone or in combination with Theileria parva parva derived from cattle and concomitant treatment with either long or short-acting formulations of oxytetracyline. At 90 or 120 days after infection, uninfected Rhipicephalus appendiculatus nymphal ticks were applied to individual immunized cattle and the resultant adults ticks were applied to individual susceptible cattle. Theilerial infection developed from ticks fed on 6 out of 11 animals investigated for evidence of a carrier state. Two additional animals were shown by cell-culture isolation to have persistent theilerial infections. Nine cattle infected with the parasites from carrier animals were treated with paravaquone and 7 recovered. These recovered cattle were then challenged with the original immunizing stabilates at 10 degrees dilution together with the original immunized and carrier cattle. Six out of 7 cattle which had recovered from carrier-derived infection succumbed to this challenge and died but none of the original immunized cattle showed theilerial reactions. When a carrier-derived sporozoite stabilate was used to chal...Continue Reading

References

Apr 1, 1976·European Journal of Immunology·G KöhlerC Milstein
Apr 1, 1983·Parasitology·D A StaggT T Dolan
Jan 1, 1984·Advances in Parasitology·H Mehlhorn, E Shein
Jan 1, 1980·Journal of Immunological Methods·T W PearsonR S Hwett
Jan 3, 1953·Nature·W O NEITZ

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Citations

Jun 5, 2003·International Journal for Parasitology·Manuel Campos, Dale L Godson
Aug 9, 2003·DNA and Cell Biology·David A Brake
Oct 20, 2009·Veterinary Parasitology·Kgomotso P SibekoNicola E Collins
Feb 15, 2001·Research in Veterinary Science·D J McKeever
Oct 17, 2002·Annals of the New York Academy of Sciences·A A LatifS Masaka

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