PMID: 8971022Dec 1, 1996Paper

Theiler's murine encephalomyelitis virus-induced cardiac and skeletal muscle disease

Journal of Virology
R M GómezR P Roos

Abstract

The DA strain of Theiler's murine encephalomyelitis virus, a member of the cardiovirus genus of picornaviruses, induces a restricted and persistent infection associated with a demyelinating process following intracerebral inoculation of mice; both virus infection and the immune response are believed to contribute to the late white matter disease. We now report that intraperitoneal inoculation with DA produces an acute myositis that progresses to a chronic inflammatory muscle disease in CD-1 mice as well as several inbred mouse strains. Some mouse strains also develop central nervous system white matter disease and a focal myocarditis. Infectious virus in skeletal muscle falls to undetectable levels 3 weeks postinoculation (p.i.), although viral genome persists for at least 12 weeks p.i., the longest period of observation. Severe combined immunodeficient animals have evidence of muscle pathology as long as 5 weeks p.i., suggesting that DA virus is capable of inducing chronic muscle disease in the absence of an immune response. The presence in immunocompetent mice, however, of prominent muscle inflammation in the absence of infectious virus suggests that the immune system also contributes to the pathology. T lymphocytes are the p...Continue Reading

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Citations

Jul 9, 2011·Journal of Medical Virology·Javier O CifuenteRicardo M Gómez
Feb 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neva B WatsonPaul T Massa
Jun 13, 2017·Clinical & Experimental Neuroimmunology·Ikuo TsunodaAh-Mee Park
Jan 24, 2019·International Journal of Molecular Sciences·Ingo GerhauserAndreas Beineke

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